Brain-Body Interaction of Breath-by-Breath O2-CO2 Exchange Ratio withResting State Cerebral Hemodynamic Fluctuations

每次呼吸 O2-CO2 交换比与静息态脑血流动力学波动的脑体相互作用

• 批准号: 10203835
• 负责人: KENNETH K KWONG
• 金额: $ 25.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203835
• 关键词: Area; Blood Flow Velocity; Brain; Brain imaging; Brain region; Breathing; Carbon Dioxide; Cerebrovascular Circulation; Cerebrum; Clinical Research; Coupling; Data; Databases; Diagnostic; Frequencies; Functional Magnetic Resonance Imaging; Future; Goals; Individual; Measurement; Measures; Metabolism; Physiological; Research; Rest; Role; Signal Transduction; Study Subject; Therapeutic; Time; Transcranial Doppler Ultrasonography; aged; base; blood oxygen level dependent; cerebral hemodynamics; cohort; healthy volunteer; improved; insight; middle cerebral artery; mind body interaction; neuroimaging; novel; respiratory; respiratory gas; uptake; Area; Blood Flow Velocity; Brain; Brain imaging; Brain region; Breathing; Carbon Dioxide; Cerebrovascular Circulation; Cerebrum; Clinical Research; Coupling; Data; Databases; Diagnostic; Frequencies; Functional Magnetic Resonance Imaging; Future; Goals; Individual; Measurement; Measures; Metabolism; Physiological; Research; Rest; Role; Signal Transduction; Study Subject; Therapeutic; Time; Transcranial Doppler Ultrasonography; aged; base; blood oxygen level dependent; cerebral hemodynamics; cohort; healthy volunteer; improved; insight; middle cerebral artery; mind body interaction; neuroimaging; novel; respiratory; respiratory gas; uptake

7. Project Summary/Abstract (No more than 30 lines) The origin of the low frequencies (below 0.05Hz) resting state cerebral hemodynamic fluctuations (CHF) in default mode network (DMN) and other resting state networks (RSNs) remains unknown. We hypothesized that CHF at low frequencies correlated with fluctuations in resting systemic metabolism obtained from respiratory gas exchange measurements (O2 uptake, CO2 release and their ratio) in spontaneous breathing. We introduced a new brain-body interaction showing a strong correlation between CHF and breath-by-breath O2-CO2 exchange ratio (bER) which is a ratio of O2 uptake to CO2 release. With transcranial Doppler sonography and functional magnetic resonance imaging, bER was shown to be better than O2 uptake which in turn was far better than CO2 release in correlation with CHF. The superiority of O2 uptake over that of CO2 release indicates that O2 uptake and CO2 release are not redundant in their correlation with CHF. The coherence of bER with CHF was shown to be significant at the frequency range between 0.03Hz and 0.008Hz with the coherence getting stronger and stronger at lower and lower frequencies. Brain regions with strong bER-CHF coupling overlapped many areas of the default mode network (DMN), suggesting a potential association between oscillations of resting systemic metabolism characterized by bER and the rhythm of background brain activities characterized by DMN. We propose to study 60 normal individuals to increase our neuroimaging data base to improve our understanding on the role of bER-CHF coupling, a brain-body interaction between systemic metabolism and resting state brain activities, especially those at DMN. Such a data base will not only support more research on the basic mechanism of DMN and other cerebral resting state oscillations but also provide opportunities for future clinical research which images brain markers for conditions that modulate respiratory gas exchange for diagnostic as well as therapeutic purposes.

7。项目摘要/摘要（不超过30行） 低频（低于0.05Hz）的静息状态脑血流动力学波动（CHF）的起源 默认模式网络（DMN）和其他静止状态网络（RSN）仍然未知。我们假设 低频的CHF与从静息全身代谢中的波动相关 自发呼吸中的呼吸气体交换测量（O2吸收，二氧化碳释放及其比率）。 我们引入了一种新的脑体相互作用，显示了CHF与呼吸呼吸 O2-CO2交换比（BER）是O2摄取与CO2释放的比率。与经颅多普勒 超声检查和功能性磁共振成像，BER被证明比O2吸收更好 与CHF相关的二氧化碳释放远比CO2释放要好得多。 O2吸收优于CO2的优势 释放表明O2摄取和CO2释放与CHF的相关性并不多余。这 证明BER与CHF的连贯性在0.03Hz和0.008Hz之间的频率范围很重要 在较低和较低的频率下，连贯性变得越来越强。大脑区域 BER-CHF耦合超过默认模式网络（DMN）的许多领域，这表明潜力 以Ber为特征的静息系统代谢的振荡与节奏的振荡 DMN为特征的背景大脑活动。我们建议研究60个普通人以增加我们的 神经影像学数据库，以提高我们对BER-CHF耦合作用的理解，脑体 全身代谢与静止状态大脑活动之间的相互作用，尤其是DMN的活动之间的相互作用。这样的 数据库不仅将支持有关DMN和其他大脑静止状态的基本机制的更多研究 振荡，但也为将来的临床研究提供了机会 这种调节呼吸道气体交换以进行诊断和治疗目的。