ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

ALS 高效联网高级光束线实验 (ALS-ENABLE)

• 批准号: 10201646
• 负责人: PAUL David ADAMS
• 金额: $ 131.02万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-09-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201646
• 关键词: Academia; Address; Adopted; Automation; Biological; California; Collection; Communities; Complement; Complex; Coupling; Crystallization; Crystallography; Data Analyses; Data Collection; Databases; Development; Education and Outreach; Educational workshop; Effectiveness; Elements; Ensure; Evaluation; Feedback; Funding Agency; Goals; Hand; Harvest; Health; Human; In Situ; Individual; Industry; Internet; Investments; Journals; Life; Light; Measurement; Methods; Modeling; Molecular Sieve Chromatography; Movement; Peer Review; Pharmaceutical Preparations; Phase; Publications; Radiation induced damage; Reporting; Research; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Route; Sampling; Services; Site; Source; Structure; Synchrotrons; System; Techniques; Technology; Temperature; Testing; Time; Training; Training Programs; United States National Institutes of Health; Work; X-Ray Crystallography; base; beamline; biological systems; data quality; design; experience; experimental study; human disease; improved; innovation; insight; meetings; novel therapeutics; operation; outreach; outreach program; programs; recruit; response; screening; service programs; structural biology; tool; web portal; web-enabled

Overall Summary/Abstract The overall goal of this proposal is to provide an integrated, efficient synchrotron structural biology Resource to the research community. This Resource, called ALS-ENABLE, will be located at the Advanced Light Source (ALS) in Berkeley, California. It will provide a transparent interface to the mature structural biology technologies at the ALS, and be designed to optimize the chances of successful structure determination for both routine and challenging problems. Multiple access mechanisms, including on site, remote, mail-in and collaborative, will be provided, and the users will be guided through the most appropriate routes for answering their biological question. The Resource will leverage the substantial investment in construction and operations by other funding agencies, industry and academia. The Resource has 3 Technology Operations Cores (TOCs) that address specific needs in the research community: 1) rapid response crystallography, 2) high quality and high throughput small angle X-ray scattering, and 3) specialized crystallography. A multifaceted training and outreach program will incorporate face-to-face training, remote and online materials, and training groups. The Resource will have a robust web presence, be represented in peer-reviewed publications, and participate in professional meetings and workshops to promote ALS-ENABLE capabilities, recruit new users, and report Resource technologies to the greater structural biology community. The Resource will be managed by an administrative core, which will ensure that local, remote, and collaborative access is maintained for peer- reviewed beamtime proposals. Based on evaluation of metrics and user feedback, we will consistently improve the user interactions through the ALS-ENABLE web portal and the experimental resources.

总体总结/摘要 该提案的总体目标是提供一个集成的、高效的同步加速器结构生物学资源 研究界。该资源称为 ALS-ENABLE，将位于高级光源处 （ALS）位于加利福尼亚州伯克利。它将为成熟的结构生物学技术提供透明的接口 在 ALS 上，旨在优化常规和常规结构确定的成功机会 具有挑战性的问题。多种访问机制，包括现场、远程、邮寄和协作，将 提供，用户将被引导通过最合适的途径来回答他们的生物问题 问题。该资源将利用其他公司在建设和运营方面的大量投资 资助机构、工业界和学术界。该资源有 3 个技术运营核心 (TOC)， 满足研究界的特定需求：1) 快速响应晶体学，2) 高质量和高 高通量小角度 X 射线散射，以及 3) 专门的晶体学。多方面的培训和 外展计划将包括面对面培训、远程和在线材料以及培训小组。这 资源将拥有强大的网络存在，出现在同行评审的出版物中，并参与 专业会议和研讨会，以推广 ALS-ENABLE 功能、招募新用户并报告 为更大的结构生物学界提供技术资源。该资源将由一个 管理核心，这将确保维护对等方的本地、远程和协作访问 审查了波束时间提案。根据指标评估和用户反馈，我们将不断改进 用户通过 ALS-ENABLE 门户网站和实验资源进行交互。