Spatial case-control studies to target the human ecology of tick-borne infections

针对蜱传感染的人类生态学的空间病例对照研究

• 批准号: 10186696
• 负责人: Andrew A Lover
• 金额: $ 19.4万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10186696
• 关键词: Acute; Address; Aftercare; Anaplasmosis; Area; Asians; Babesiosis; Behavior; Borrelia burgdorferi; Case-Control Studies; Classification; Clinic Visits; Collection; Data; Demographic Factors; Dengue; Development; Diagnosis; Ecology; Enrollment; Epidemiology; Evidence based intervention; Foundations; Geographic Locations; Geography; Global Positioning System; Goals; Haemaphysalis longicornis; Health; Heterogeneity; Hospitals; Human; Individual; Infection; Infrastructure; Intervention; Intervention Trial; Laboratories; Location; Lyme Disease; Malaria; Massachusetts; Measures; Methodology; Methods; Minority; Modeling; Modification; Neighborhoods; Occupations; Outcome; Ownership; Participant; Pattern; Persons; Pesticides; Population Surveillance; Positioning Attribute; Prevalence; Public Health; Questionnaires; Reporting; Research Personnel; Resolution; Risk; Risk Factors; Sampling; Site; Surveillance Program; Surveys; System; Tick Control; Tick-Borne Diseases; Tick-Borne Infections; Ticks; United States; Vector-transmitted infectious disease; acaricide; authority; burden of illness; case control; clinical encounter; cost; cost effective; density; design; disease transmission; disorder risk; feasibility testing; high risk; improved; infection risk; meteorological data; novel; pathogen; pathogen exposure; peri-urban; programs; rural area; sex; tick population; tick-borne pathogen; tool; transmission process; vector; vector tick

SUMMARY/ABSTRACT Human infections with Borrelia burgdorferi (Bb) the causative agent of Lyme disease, and other tick-borne pathogens are major and emerging health threats in the United States. The geographic range of tick vectors is expanding within the US, and new tick species are being introduced including Haemaphysalis longicornis (the Asian longhorned tick), an invasive species which is a vector for several human infections. While many state- and local-level jurisdictions have tick surveillance programs, these by necessity cover large geographic areas leading to increased expense and inefficiency. As a consequence, fundamental aspects of the epidemiology of tick-borne diseases remain obscure; and no methods currently exist to identify and target physical locations with highest risk for tick-borne disease transmission. Therefore, the studies proposed here are directed to understanding key aspects of the connections between human outdoor activities and tick populations to develop more targeted health surveillance programs. First, we will enroll both persons with confirmed tick- borne disease and those without, and we will assess risk factors for infection. We will then capture and compare human mobility patterns in both groups using geographic position system (GPS) data loggers; these data will be used to identify locations of significant risk. Secondly, we will perform comprehensive tick surveys at all locations with either high or low risk, and will compare tick abundance and pathogen prevalence between sites to confirm results from the spatial analysis. Our findings will dramatically expand our ability to directly and efficiently target surveillance and interventions to address a critically important public health problem.

摘要/摘要 伯氏伯氏菌（BB）的人类感染是莱姆病的病因和其他tick传播的药物 病原体是主要的，在美国有新兴的健康威胁。 tick矢量的地理范围 在美国范围内扩展，正在引入新的壁虱物种，包括Haemaphysalis longicornis （亚洲长角虱），一种入侵物种，是几种人类感染的媒介。而很多 州和地方层面的司法管辖区具有tick监视计划，这些计划必要涵盖了大量 地理区域导致费用增加和效率提高。结果， tick传播疾病的流行病学仍然晦涩难懂。并且目前没有任何方法可以识别和 目标物理位置具有tick传播疾病的风险最高的物理位置。因此，研究 这里提出的旨在理解人类户外联系的关键方面 活动和tick人群以制定更有针对性的健康监视计划。首先，我们将注册 两个患有确认tick病的人和没有疾病的人，我们将评估风险因素 感染。然后，我们将使用地理位置捕获和比较两组的人类流动性模式 位置系统（GPS）数据记录器；这些数据将用于确定具有重大风险的位置。第二， 我们将在风险高或低风险的所有位置进行全面的壁虱调查，并将比较tick 位点之间的丰度和病原体患病率，以确认空间分析的结果。我们的发现 将大大扩展我们直接有效地针对监视和干预措施解决的能力 至关重要的公共卫生问题。