Eukaryotic Gene Regulation (EGR) Predoctoral Training Program

真核基因调控（EGR）博士前培训项目

• 批准号: 10179424
• 负责人: JOSEPH C REESE
• 金额: $ 18.39万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179424
• 关键词: Gene Expression Regulation; Training Programs; pre-doctoral

PROJECT SUMMARY The Penn State ‘Eukaryotic Gene Regulation (EGR) Predoctoral Training Program’ will train a future generation of scientists in experimental, molecular and computational sciences applied towards understanding mechanisms of eukaryotic gene regulation. The training program will build upon established graduate programs in biochemistry, molecular, cellular and developmental biology, bioinformatics and genomics. The goals of the EGR program are consistent with the Cellular, Biochemical and Molecular Sciences (CMB) program at National Institute of General Medicine. The program aims to cultivate interdisciplinary study and the training of new scientists pertaining to biological problems and cellular and molecular sciences to advance science and improve health. Nearly all aspects of biology and human disease are rooted in gene regulation. Our knowledge and abilities to understand, control, and rectify gene expression and mis-expression is fundamental to the basic knowledge cells and to the basic knowledge of medicine. A recent report from the American Cancer Society finds that we are winning the war on cancer in part because of our understanding of fundamental mechanisms of gene control. However, it is also clear that we must keep up the fight. This fight will require scientists cross-trained in experimental and computational sciences. The proposed EGR training program will train a diverse cohort of student-scientists to have critical expertise in biophysics, biochemistry, molecular biology, genetics, computational biology, and statistics to address fundamental questions in gene regulation. The program will be anchored within the Center for Eukaryotic Gene Regulation (CEGR), which has been chartered to these principles for over 20 years. Penn State’s CEGR has a long-standing reputation for producing outstanding science. This training program will connect and further develop five established graduate programs: Biochemistry and Molecular Biology (BMMB), Chemistry (CHEM), Chemical Engineering (CHE), Molecular Cellular and Integrative Biosciences (MCIBS), and Bioinformatics and Genomics (MCIBS-BG). Combining NIH and Penn State support, the EGR program plans to train a minimum of 13 predoctoral students over a period of five years. Each trainee will be supported for the two years of their training (year 2 and 3) while receiving foundational training in EGR. Trainees will gain a thorough understanding of the scientific process, responsible conduct in science, fluency in innovative research methodologies, ability to utilize genomics and statistical tools in advancing genome-wide experimental approaches, excellence in cross-disciplinary communication, and leadership in cross-disciplinary research teams.

项目摘要 宾夕法尼亚州立大学“真核基因调节（EGR）训练计划”将训练未来的一代 在实验，分子和计算科学领域的科学家应用于理解机制 真核基因调节。培训计划将建立在既定的研究生课程的基础上 生物化学，分子，细胞和发育生物学，生物信息学和基因组学。 EGR的目标 程序与国家的细胞，生化和分子科学（CMB）计划一致 通用医学研究所。该计划旨在培养跨学科研究和新的培训 与生物学问题以及细胞和分子科学有关的科学家，以提高科学并改善 健康。生物学和人类疾病的几乎所有方面都植根于基因调节。我们的知识和 理解，控制和纠正基因表达和错误表达的能力是基本的基础 知识细胞和医学的基本知识。美国癌症协会的最新报告发现 我们之所以赢得癌症战争的部分原因是我们对基因的基本机制的理解 控制。但是，很明显，我们必须继续战斗。这场战斗将需要科学家进行交叉训练 实验和计算科学。拟议的EGR培训计划将培训潜水员队列 学生科学家在生物物理学，生物化学，分子生物学，遗传学， 计算生物学和统计数据，以解决基因调节中的基本问题。该程序将是 锚定在真核基因调节中心（CEGR）中，该中心已被包裹 超过20年的原则。宾夕法尼亚州立大学的CEGR对生产出色的评论有一份长期评论 科学。该培训计划将连接并进一步开发五个既定研究生课程：生物化学 和分子生物学（BMMB），化学（化学），化学工程（CHE），分子细胞和 综合生物科学（MCIBS）以及生物信息学和基因组学（MCIBS-BG）。结合NIH和Penn 国家支持，EGR计划计划在五年的时间内培训至少13名专业学生。 在接受基础的同时，将在培训的两年（第2年和3年）中支持每个学员 EGR培训。受训人员将对科学过程有透彻的理解，负责任的行为 科学，创新研究方法的流利程度，利用基因组学和统计工具的能力 推进全基因组的实验方法，跨学科交流的卓越和 跨学科研究团队的领导。