The influence of repetitive head impacts on motion perception

重复头部撞击对运动感知的影响

• 批准号: 10187694
• 负责人: Nicholas Murray
• 金额: $ 21.63万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10187694
• 关键词: Athletic; Behavior; Blindness; Brain; Brain Concussion; Characteristics; Control Groups; Data; Diagnosis; Eye Abnormalities; Eye Movements; Impairment; Institutes; Investigation; Knowledge; Manufactured football; Mission; Motion Perception; National Institute of Neurological Disorders and Stroke; Neurologic; Neurosciences; Observational Study; Participant; Performance; Research; Risk; Saccades; Seasons; Smooth Pursuit; Sports; Testing; Time; Visual Acuity; Visual Perception; base; behavioral impairment; head impact; innovation; nervous system disorder; novel; oculomotor; recruit; response; student athlete

The objective of this application will be to determine the lasting consequences of repetitive head impacts (RHIs) on motion perception and oculomotor response during dynamic visual acuity (DVA). The specific aims of this project are to (1) examine the effect of RHI on oculomotor control over a single athletic season and (2) does RHIs impair motion perception after a single athletic season? The proposed research is consistent with NINDS’s mission to seek fundamental knowledge about the brain to use that knowledge to reduce the burden of neurological disease. It is hypothesized the presence of RHIs will result in smooth pursuit gain, saccadic magnitude and peak saccadic velocity decreases along with a loss of visual acuity during the DVA tasks over the single season of contact sports. To test these hypotheses, the proposed research will institute a observational study that involves assessing oculomotor control and behavior on adaptive DVA tasks from pre-, mid-, and post-season of a single season of RHIs, that are independent of a sport-related concussion, as compared to non-RHIs controls. Thirty-five athletes from both the RHIs and control group will be recruited from Division I student-athlete football players and non-contact controls. Participants will be excluded if they have a diagnosed sport-related concussion during the single athletic season or if they have a prior existing neurological condition. Based on the pilot data, it is expected to see impaired smooth pursuit gain and saccadic mean/peak velocity in the RHI group over time. It is predicted this will lead to visual acuity loss and impaired behavioral performance in visual perception tasks. This project is innovative as little is known regarding the consequence of RHIs. The findings will be the first to assess if motion perception is altered as a result of RHIs and whether this potential DVA loss is a result of abnormal eye movements. In addition, this study will be the first to examine the characteristics of SPEMs and saccades in the presence of RHIs. These novel investigations have not been previously established and should be further evaluated to understand the risk of RHIs.

该应用的目的是确定重复头部撞击 (RHI) 对动态视力 (DVA) 期间运动感知和动眼神经反应的持久影响。该项目的具体目标是 (1) 检查 RHI 对运动感知和动眼神经反应的影响。单个运动赛季的动眼神经控制以及（2）RHI 是否会在单个运动赛季后损害运动知觉？ 拟议的研究与 NINDS 的使命一致，即寻求有关大脑的基础知识，并利用这些知识来减轻运动负担？神经系统疾病。据认为，RHI 的存在会导致在单赛季接触运动的 DVA 任务中平滑追踪增益、扫视幅度和峰值扫视速度降低以及视力丧失。研究将开展一项观察性研究，涉及评估单赛季 RHI 的季前、季中和季后适应性 DVA 任务的动眼控制和行为，这些任务独立于与运动相关的因素与非 RHI 对照组相比，来自 RHI 和对照组的 35 名运动员将从一级学生运动员足球运动员中招募，如果参与者被诊断为与运动相关，则将被排除在外。根据试点数据，预计 RHI 组的平滑追踪增益和扫视平均/峰值速度会随着时间的推移而受损。导致视力丧失和视觉感知任务中的行为表现受损，该项目具有创新性，因为人们对 RHI 的后果知之甚少，该研究结果将首次评估运动知觉是否会因 RHI 而改变以及这种潜力是否会改变。 DVA 损失是眼球运动异常的结果。此外，这项研究将首次检查 RHI 存在下的 SPEM 和眼跳的特征，这些新颖的研究此前尚未建立，应进一步评估以了解风险。的RHI。