Virtual Reality-based Rehabilitation for Children with Traumatic Brain Injuries

基于虚拟现实的脑外伤儿童康复

• 批准号: 10178242
• 负责人: Jiabin Shen
• 金额: $ 24.89万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10178242
• 关键词: 3-Dimensional; Accounting; Address; Adherence; Adverse event; Age; Attention; Award; Brain Injuries; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Development; Childhood; Clinical; Clinical Trials; Cognitive; Computer software; Congresses; Control Groups; Coupled; Data; Development; Doctor of Philosophy; Effectiveness; Emotional; Ensure; Family; Fostering; Future; Goals; Grant; Health; Healthcare; Home environment; Immersion; Impaired cognition; Impairment; Inpatients; Internet; Intervention; Interview; Knowledge; Life; Measures; Mediating; Mentors; Mentorship; Mission; National Institute of Child Health and Human Development; Outcome; Outcome Assessment; Pathway interactions; Pediatric Hospitals; Phase; Positioning Attribute; Postdoctoral Fellow; Quality of life; Randomized; Randomized Clinical Trials; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Research; Research Institute; Research Personnel; Research Priority; Research Training; Safety; Sample Size; Scholarship; Scientist; Services; Short-Term Memory; Structure; Technology; Testing; Training; Training Activity; Training Programs; Transferable Skills; Trauma; Trauma Research; Traumatic Brain Injury; Treatment Efficacy; Visit; base; career; career development; cognitive function; cognitive rehabilitation; cognitive skill; cognitive training; computerized; design; disability; evidence base; executive function; experience; flexibility; follow-up; frontal lobe; functional improvement; group intervention; health related quality of life; improved; innovation; long-term rehabilitation; mobile computing; multidisciplinary; novel; pediatric trauma; post intervention; professor; programs; psychologic; recruit; rehabilitation research; research and development; safety and feasibility; severe injury; skills; social rehabilitation; tenure track; theories; virtual environment; virtual reality; virtual reality game; virtual reality system

Jiabin Shen, PhD, is a Research Scientist (postdoc equivalent position) in the Center for Pediatric Trauma Research at The Research Institute at Nationwide Children’s Hospital (NCH). His long-term career goal is to become an accomplished research scientist with a programmatic line of research focused on theory-driven and technology-assisted psychological rehabilitation for childhood TBI. Childhood TBI is a leading cause of acquired disability in U.S. children with 700,000 cases every year, which often result in significant impairment in broad cognitive functions, particularly in executive functions (EFs) that are critical to children’s development, especially in children with moderate to severe TBI. Although the Centers for Disease Control and Prevention (CDC) has identified post-TBI cognitive rehabilitation as the top unmet health care need for children with TBI, interventions specifically designed for children’s EF rehabilitation post-TBI remain unavailable. Virtual reality (VR) offers exciting potential as an alternative strategy for EF rehabilitation of childhood TBI for its flexibility in training content, capability for affordable remote access, and potential of increased adherence and skill transfer. However, the safety/efficacy of VR-based EF rehabilitation of childhood TBI remains to be established. This Pathway to Independence Award (K99/R00) proposal outlines structured career development and research plans aiming to assess the safety and efficacy of an innovative VR-based EF training program for children with moderate to severe TBI. During the K99 phase, Dr. Shen will conduct a small parallel-group randomized clinical trial (RCT) to evaluate the VR research paradigm, safety, and preliminary efficacy of the intervention among 30 children 7-17 years with moderate to severe TBI. Coupled with a structured training plan, the K99 phase will help Dr. Shen gain expertise in: (1) childhood TBI rehabilitation and outcome assessment, (2) technology-assisted childhood TBI rehabilitation, and (3) advanced design and analysis for RCTs in pediatric rehabilitation settings. Dr. Shen’s research and training during the K99 phase will be supported by the mentorship of an established and multidisciplinary team with extensive expertise in guiding trainees to successful academic careers as independent investigators, as well as the Inpatient Rehabilitation Unit and research core services at NCH. Along with the career development support from his Scholarship Oversight Committee, the K99 award will ensure Dr. Shen’s successful transition to the R00 phase as an independent tenure-track assistant professor in pediatric rehabilitation research. During the R00 phase, Dr. Shen will conduct a full-scale parallel-group RCT to formally evaluate the efficacy of the VR program on children’s core EFs, daily EFs, attention problems, and health-related quality-of-life outcomes. The expertise and skills gained from this K99/R00 award will inform the development of a comprehensive VR program for cognitive, emotional, and social rehabilitation among children with TBI and other acquired brain injuries.

Jiabin Shen博士是小儿创伤中心的研究科学家（博士后当量位置） 全国儿童医院（NCH）研究所的研究。他的长期职业目标是 成为一名有成就的研究科学家，具有针对理论驱动和的计划研究线 技术协助的心理康复，用于儿童期TBI。童年时期TBI是主要原因 每年有700,000例病例的美国儿童获得的残疾，这通常会导致重大损害 在广泛的认知功能中，特别是在对儿童成长至关重要的行政职能（EFS）中 特别是在中度至重度TBI的儿童中。尽管疾病控制与预防中心 （CDC）已确定TBI后认知康复是TBI儿童的最佳未满足医疗保健需求 专为TBI后专门为儿童康复设计的干预措施仍然不可用。虚拟现实 （VR）提供了令人兴奋的潜力，作为EF修复儿童时TBI的替代策略的灵活性 培训内容，负担得起的远程访问能力以及依从性和技能转移的潜力。 但是，基于VR的EF修复儿童TBI的安全/功效仍有待确定。 这项获得独立奖的途径（K99/R00）提案概述了结构化职业发展和 研究计划旨在评估基于VR的创新EF培训计划的安全性和效率 中度至重度TBI的儿童。在K99阶段，Shen博士将进行一个小的平行组 随机临床试验（RCT）评估VR研究范式，安全性和初步有效性 7-17岁的30名儿童干预中度至重度TBI。再加上结构化培训计划， K99阶段将帮助Shen博士获得以下方面的专业知识：（1）儿童tbi康复和结果评估， （2）技术辅助的儿童TBI康复，以及（3）RCT的高级设计和分析 小儿康复环境。 Shen博士在K99阶段的研究和培训将得到 一支拥有广泛专业知识的成熟且多学科团队的遗产，指导学员 作为独立研究人员以及住院康复部门的成功学术职业和 NCH的研究核心服务。 除了他的奖学金监督委员会的职业发展支持外，K99奖将 确保Shen博士成功过渡到R00阶段，成为独立的终身助理助理教授 小儿康复研究。在R00阶段，Shen博士将进行全尺度平行组RCT 正式评估VR计划在儿童核心EF，每日EFS，注意问题和 与健康相关的生活质量结果。该K99/R00奖中获得的专业知识和技能将告知 制定儿童认知，情感和社交康复的全面VR计划 与TBI和其他获得的脑损伤有关。