NHD Permetium Multimodal Imaging System

NHD Permetium 多模态成像系统

• 批准号: 10175734
• 负责人: Brian D. Ross
• 金额: $ 60万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175734
• 关键词: Air Movements; Airway Disease; Anatomy; Animal Model; Applications Grants; Arteries; Basic Science; Blood Vessels; Cancer Model; Core Facility; Data; Devices; Diagnostic; Disease; Disease model; Ensure; Environment; Environmental Wind; Equipment; Evaluation; Four-dimensional; Funding; Heart; Image; Institution; Laboratories; Legal patent; Lung; Maintenance; Medicine; Michigan; Movement; Multimodal Imaging; Nature; Phase; Physiology; Recording of previous events; Research; Research Personnel; Roentgen Rays; Series; Technology; Technology Assessment; Translational Research; United States National Institutes of Health; Universities; Vascular remodeling; Velocimetries; animal imaging; base; contrast imaging; heart imaging; high resolution imaging; imaging system; instrument; instrumentation; lung imaging; molecular imaging; novel drug class; operation; particle; pre-clinical; programs; pulmonary function; quantitative imaging; tool; ultra high resolution

PROJECT SUMMARY/ABSTRACT The overall objectives of this NIH S10 Instrumentation grant application is to request funds to purchase a newly available Notting Hill Devices (NHD) Preclinical Scanner. This instrument will allow investigators with unprecedented quantitative imaging of lung function and vascular changes for deciphering lung airway disease along with evaluation of cardiothoracic vascular remodeling in small animal models. This patented Australian technology also known as 4-Dimensional X-ray Velocimetry (4DXV) is based on the wind tunnel technology known as particle image velocimetry and is the only commercially available device for ultra-high resolution imaging and quantification of cardiothoracic disease models. The penetrating nature of X-rays is used to capture a series of temporal phase-contrast images of the lungs, heart and associated vascular. Velocimetry is used to determine the movement of an anatomical structure from one image to the next, providing information on both velocity and direction of movement. Images are paired and discretized into small sub-regions and cross- correlations performed between the sub-regions in consecutive images. The resulting 4-dimentional lung images show arteries and lungs and provides functional airflow and pulmonary vasculature data of the lungs with detailed quantification of airflow and vasculature in specific regions of the airways. The 4DX scanner provides a safe, quick, and inexpensive tool that not only provides high-resolution images but also yields detailed, regional information on lung function. The University of Michigan Center for Molecular Imaging has a rich history of contributions in basic science and in medicine and provides overall imaging support to the entire academic institution through establishment and maintenance of a small animal imaging core facility historically focused on cancer models. The addition of the 4DXV instrument equipment will be utilized by a group of NIH-funded, established, senior investigators. The 4DXV Preclinical Scanner is an indispensable necessity for the cardiothoracic translational research efforts which include evaluation of novel classes of drugs focused on treatment of cardiothoracic diseases. The scanner will be housed is a well-established Animal Model and Imaging Core with strong commitment from the University of Michigan Center for Molecular Imaging to establish an institutional Preclinical Lung and Heart Physiology Shared Laboratory to ensure long-term maintenance and operation of the instrument. Importantly, the scanner will provide for a paradigm shift in lung research and diagnostics. 4DVX is a promising and powerful technology for assessment of cardiothoracic diseases. The University of Michigan presents a near ideal environment in which to initiate such a research program within an established small animal imaging core facility.

项目摘要/摘要 该NIH S10仪器授予申请的总体目标是要求资金购买新的 可用的诺丁山设备（NHD）临床前扫描仪。该工具将允许调查人员与 肺功能的空前定量成像和肺气道疾病的血管变化 以及评估小动物模型中心胸血管重塑的评估。这是澳大利亚专利的 技术也称为4维X射线速度法（4DXV）基于风洞技术 被称为粒子图像速度法，是唯一用于超高分辨率的市售设备 心胸疾病模型的成像和定量。 X射线的穿透性用于捕获 肺，心脏和相关血管的一系列时间相对比图像。速度法用于 确定解剖结构从一个图像到另一个图像的移动，提供有关两者的信息 速度和运动方向。将图像配对并离散为小子区域，并交叉 连续图像中子区域之间执行的相关性。由此产生的4维肺图像 显示动脉和肺部，并提供肺部功能性气流和肺脉管数据 气流和脉管系统的特定区域中的量化。 4DX扫描仪提供了安全的 快速且廉价的工具，不仅提供高分辨率图像，而且可以产生详细的区域性 有关肺功能的信息。 密歇根大学分子成像中心拥有丰富的基础科学贡献史和 在医学领域，并通过建立为整个学术机构提供整体成像支持 维持一个小动物成像核心设施历史上以癌症模型为重点。加法 4DXV仪器设备将由一群由NIH资助的，已建立的高级调查员使用。这 4DXV临床前扫描仪是心胸翻译研究工作必不可少的必要性 其中包括评估针对心胸疾病治疗的新型药物。扫描仪 将被安置是一个公认的动物模型和成像核心，并具有大学的坚定承诺 密歇根州分子成像中心建立机构临床前肺和心脏生理 共享实验室，以确保仪器的长期维护和运行。重要的是，扫描仪 将规定肺部研究和诊断范围的范式转移。 4DVX是评估心胸疾病的有前途且有力的技术。大学 密歇根州提出了一个近乎理想的环境，在该环境中启动这种研究计划 小动物成像核心设施。