Spectrometer Upgrade for a Small Animal Imaging Core MRI

小动物成像核心 MRI 光谱仪升级

• 批准号: 10175413
• 负责人: EDWARD J YURKOW
• 金额: $ 22.56万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175413
• 关键词: Animals; Beds; Body Temperature; Calibration; Cardiac; Computer software; Computers; Core Facility; Cost Savings; Evaluation; Failure; Funding; Generations; Head; Heating; Histologic; Image; Magnetic Resonance Imaging; Manuals; Modeling; Monitor; Mus; Optics; Organ; PET/CT scan; Periodicity; Physiologic pulse; Rattus; Research; Resolution; Respiration; Rodent; Roentgen Rays; Scanning; System; Time; Tissues; Ultrasonography; aged; analog; animal imaging; base; design; digital; imaging modality; imaging system; improved; molecular imaging; radio frequency

Abstract Funds are requested for the acquisition of a digital spectrometer and auto-calibrating radiofrequency (RF) coils needed to upgrade our existing 1T static magnet MRI imaging system located in a multiuser imaging core facility. The spectrometer will replace an aged analog spectrometer that is currently controlling the RF coils. Our current analog spectrometer has been used for >85,000 scans over a 9- year period and is now prone to periodic failure during scanning sessions. The analog system also requires manual calibration of the RF coils several times throughout the day, which increases imaging session times and scan variability. The new digital spectrometer has increased capabilities compared to the analog unit, including improved and additional preprogrammed pulse sequences that will be particularly useful to the many research groups using the system. The digital spectrometer also captures respiration- and cardiac-gated images which is not possible with the current analog system. The funds requested will also be used to purchase a complete set of auto-calibrating RF coils including whole body rat, whole body mouse as well as high resolution rat head and mouse head coils. The mouse head coil can also be used for high-resolution scanning of isolated tissues and organs prior to histological processing and evaluation. The requested coils are designed to interface directly with the digital spectrometer and to fit the magnet bore of our specific MRI model. In addition, unlike our current RF coils and animal scanning beds, these coil/bed sets are heated to maintain the body temperature of anesthetized rodents during imaging. The spectrometer and RF coil upgrades are fully compatible with the 1T magnet base unit, which will be retained, thus saving cost over the purchase a totally new complete system. The upgraded MRI system, which includes the digital spectrometer and the four, “new generation” RF coils, upgraded controller computer, new acquisition software, animal bed heating system and animal monitor used for respiration and cardiac gating, will be housed in the same room in place of our current unit within a multiuser academic molecular imaging center which also maintains other imaging modalities including PET/CT, Ultrasound, Optical/X ray and nanoCT.

抽象的 要求资金获取数字光谱仪和自动校准射频 （RF）升级位于多源中的现有1T静态磁铁MRI成像系统所需的线圈 成像核心设施。光谱仪将取代当前的老年模拟光谱仪 控制RF线圈。我们目前的模拟光谱仪已在9--上使用> 85,000张扫描 一年期，现在容易在扫描过程中进行周期失败。模拟系统也 需要全天几次对RF线圈进行手动校准，这增加了成像 会话时间和扫描变异性。新的数字光谱仪比较功能增加 到模拟单元，包括改进和其他预编程的脉冲序列 对于使用该系统的许多研究小组，特别有用。数字光谱仪也 捕获当前模拟系统无法使用的呼吸和心脏门控图像。 所需的资金还将用于购买一套完整的自动校准的RF线圈 全身大鼠，全身鼠标以及高分辨率大鼠头和小鼠头线圈。这 小鼠头线圈也可以用于对孤立组织和器官进行高分辨率扫描 组织学处理和评估。请求的线圈设计为直接与 数字光谱仪并适合我们特定MRI模型的磁铁孔。此外，与我们的当前不同 RF线圈和动物扫描床，这些线圈/床套件被加热以保持体温 成像过程中麻醉啮齿动物的。光谱仪和RF线圈升级完全兼容 使用1吨磁铁基数单元将保留，从而节省了一份全新的成本 完整的系统。升级的MRI系统，包括数字光谱仪和四个， “新一代” RF线圈，升级的控制器计算机，新的采集软件，动物床供暖 用于呼吸和心脏控球的系统和动物监测器将安置在同一房间中 当前单元在多源学术分子成像中心中的地点，该中心也保持 其他成像方式，包括PET/CT，超声，光学/X射线和纳米CT。