Longevity Consortium

长寿财团

• 批准号: 10174197
• 负责人: STEVEN RON CUMMINGS
• 金额: $ 27.04万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10174197
• 关键词: Affect; Animal Model; Belief; Cells; Centenarian; Complement; Disease; Funding; Goals; Human; Leadership; Longevity; Mediating; Molecular; Mus; Pathway interactions; Pharmacology; Phenotype; Physiological Processes; Plant Roots; Play; Price; Process; Proteomics; Recording of previous events; Research; Research Personnel; Research Project Grants; Role; Structure; Study models; System; Systems Biology; age related; analytical method; cohort; data dissemination; genetic variant; healthspan; high throughput screening; metabolomics; novel; protein metabolite; web site

ABSTRACT: THE LONGEVITY CONSORTIUM (LC). Multiple studies of model organisms and humans have suggested that genetic variants, proteins, metabolites, as well as other biomolecules and molecular- physiologic processes, could play roles in mediating longevity, healthspan, and age-related disease in humans. Unfortunately, the direct relevance of many of these factors to human longevity, healthspan and age-related disease is uncertain, as is the amenability of these factors to pharmacological modulation. Therefore, well-integrated and sophisticated research strategies are needed to determine the degree to which various factors both influence human longevity and are amenable to pharmacological manipulation. The Longevity Consortium (LC) has a history of precedent-setting studies seeking to identify factors that influence human longevity and healthspan and has recently redefined its goals and research strategies to achieve an appropriate level of integration and sophistication to elucidate additional factors affecting longevity, as well as their interactions and translatability into targets for pharmacotherapeutic manipulation. To enable appropriate integration in human longevity research, the LC will exploit a multiple investigator structure with 5 interlinked research projects and 3 integrative cores. These projects and cores will include: A cross-species project focusing on cellular and organismal phenotypes led by Richard Miller (referred to as the Miller-Mice/Cell project hereafter); a metabolomics project led by Oliver Fiehn (Fiehn-Metabolomics); a Centenarians project co-led by Thomas Perls and Paola Sebastiani (Perls- Centenarian); a proteomics project led by Eric Orwoll (Orwoll-Proteomics) and a disease context project led by Nicholas Schork (Schork-Disease Context). The cores include a Systems Biology core led by Nathan Price (Price-Systems), a Chemoinformatics core led by Thomas Girke (Girke-Chemoinformatics), and an administrative core with an overall administrative component led by Steve Cummings (Cummings-Admin) and a scientific integration component led by Nicholas Schork. Drs. Cummings and Schork, as Multiple PIs, will share responsibility for the overall leadership of the LC effort. The proposed LC will complement, and partner with, an NIA-funded U24 project (U24AG051129) involving many LC investigators to construct a website for data dissemination. 1

摘要：长寿联盟 (LC)。对模式生物和人类的多项研究表明 表明遗传变异、蛋白质、代谢物以及其他生物分子和分子- 生理过程，可能在介导长寿、健康寿命和与年龄相关的疾病方面发挥作用 人类。不幸的是，其中许多因素与人类的寿命、健康寿命和寿命直接相关。 与年龄相关的疾病是不确定的，这些因素对药物调节的顺应性也是不确定的。 因此，需要充分整合和复杂的研究策略来确定 多种因素都会影响人类的寿命，并且可以通过药物控制。这 长寿联盟 (LC) 有着开创先例的研究历史，旨在找出影响健康的因素 影响人类寿命和健康寿命，最近重新定义了其目标和研究 实现适当水平的集成和复杂性的策略，以阐明额外的 影响寿命的因素，以及它们之间的相互作用和转化为长寿目标的能力 药物治疗操作。为了能够适当整合人类长寿研究，LC 将利用由 5 个相互关联的研究项目和 3 个综合核心组成的多研究者结构。这些 项目和核心将包括： 一个跨物种项目，重点关注细胞和有机体表型，由 Richard Miller（以下简称 Miller-Mice/Cell 项目）；奥利弗领导的代谢组学项目 Fiehn（Fiehn-代谢组学）；由 Thomas Perls 和 Paola Sebastiani（Perls- 百岁老人）； Eric Orwoll 领导的蛋白质组学项目（Orwoll-Proteomics）和疾病背景项目 作者：Nicholas Schork（Schork 疾病背景）。这些核心包括由 Nathan 领导的系统生物学核心 Price (Price-Systems)，由 Thomas Girke (Girke-Chemoinformatics) 领导的化学信息学核心，以及 行政核心，整体管理部分由 Steve Cummings（Cummings-Admin）领导 以及由 Nicholas Schork 领导的科学整合部分。博士。卡明斯和肖克作为多个 PI， 将分担 LC 工作的总体领导责任。拟议的信用证将补充，并且 与 NIA 资助的 U24 项目 (U24AG051129) 合作，该项目涉及许多 LC 研究人员，以构建一个 数据发布网站。 1