Microbiology: Whole Genome Sequencing (LOW) (9/1/2020-8/31/2025)

微生物学：全基因组测序（低）（9/1/2020-8/31/2025）

• 批准号: 10176065
• 负责人: Stephanie Van Hooser
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176065
• 关键词: Microbiology; Whole; Genome; Sequencing; LOW

Discipline A: Microbiology Track 4: Whole Genome Sequencing Abstract: The Nevada State Public Health Laboratory (NSPHL) seeks to maintain the capacity and capability to perform Whole Genome Sequencing (WGS) on foodborne illness pathogens. WGS studies show the relatedness of isolates to other identified isolates uploaded to various tracking databases. This allows officials to monitor pathogen genetic sequences and determine if there are clusters or widespread pockets of “like” organisms being reported. Such real-time review of organisms identified nationally, allows investigators to be alerted of a potential issue and to initiate an investigation of foods consumed by sickened individuals and/or pathogens identified from surveillance/outbreak related food items. This ability to monitor food related pathogens detected nationally provides the ability to recognize tainted foods and elicit a rapid response to remove the foods from markets to protect the public.

学科A：微生物学轨道4：整个基因组测序 抽象的： 内华达州公共卫生实验室（NSPHL）试图保持能力 以及在食源性疾病上执行整个基因组测序（WGS）的能力 病原体。 WGS研究表明分离株与其他已鉴定的分离株的相关性 上传到各种跟踪数据库。这使官员可以监测病原体 遗传序列，并确定“ like”的簇或宽度袋 有机体正在报告。对全国确定生物的这种实时审查， 允许调查人员提醒潜在的问题，并开始调查 病人和/或从中发现的病原体消耗的食物 监视/爆发相关食品。这种监测相关病原体的能力 在全国范围内发现的能力可以识别受污染的食物并迅速引起 回应从市场上清除食物以保护公众。