Hoarding disorder in older adults: cognition, etiology and functional impact

老年人囤积障碍：认知、病因和功能影响

基本信息

批准号：
10171917
负责人：
Robert Scott Mackin
金额：
$ 58.69万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-26 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10171917
关键词：
Adolescence Adult Affect Age Aging Alzheimer&apos s Disease Attention deficit hyperactivity disorder Brain Health Registry Cessation of life Chronic Chronic Disease Clinical Clinical Trials Code Cognition Cognitive Complex Compulsive Hoarding Data Death Rate Development Diagnosis Disease Early identification Elderly Enrollment Epidemiology Etiology Family Family history of Fire - disasters Frequencies Frontotemporal Dementia Genetic Genetic Diseases Genetic Risk Genetic Variation Health Heritability Home Individual Intervention Interview Lead Learning Life Expectancy Longevity Medical Mental Depression Mental disorders Neurocognitive Deficit Neurodegenerative Disorders Neurodevelopmental Disorder Neurologic Neuropsychology Obesity Obsessive-Compulsive Disorder Parkinson Disease Participant Patient Self-Report Persons Phenotype Psychiatric Diagnosis Public Health Quality of life Reporting Research Research Personnel Resources Risk Role Safety Sampling Self Care Severities Societies Symptoms Time Variant Vulnerable Populations Work aged cognitive function cognitive process comorbidity design disability disability impact early onset effective therapy fall risk frailty functional disability functional status genetic architecture improved information processing interest memory process nervous system disorder neuroimaging neuropsychiatry patient population visual learning visual memory

项目摘要

Hoarding Disorder (HD) is a common, chronic and debilitating psychiatric disorder that disproportionately affects older adults, and has a profound public health impact on individuals, families and society. While safety risks associated with clutter in HD has been consistently documented (i.e. up to 25% of deaths by house fire are due to hoarding), the true extent of disability in this patient population is not known. Further, factors contributing to disability in older adults with HD, including cognitive factors, have not been adequately clarified. Emerging data, including work from our group, suggest that deficits in specific cognitive domains are common across the lifespan in HD. This project will examine the functional impact of HD in older adults – specifically, the relationships among cognitive functioning, hoarding symptom severity, and disability. Further, we will assess the genetic risk profile of HD, and the association of HD with medical and psychiatric comorbidities that also impact disability. To achieve our aims, we will combine in-person clinical, neuropsychological, and medical frailty assessments with a unique epidemiologic resource, the online Brain Health Registry (BHR; www.brainhealthregistry.org). The BHR, which was designed to accelerate participation in clinical trials of aging and aging- related disorders, has, in three years, enrolled over 54,000 subjects who are expressly interested in participating in ongoing research with 1000 new participants enrolling every month. Nearly half (47%) of participants are ages 60 and older. Participants are well characterized in regard to psychiatric, neurological, family and medical history, and are followed longitudinally with re-assessments every six months. Identifying factors related to disability in older adults with HD will inform the development of more effective treatment interventions in this vulnerable population and offers significant promise for improving quality of life.

ho积疾病（HD）是一种常见，慢性和使人衰弱的精神障碍，对老年人的影响不成比例，对个人有深远的影响，家庭和社会。虽然与HD中混乱相关的安全风险一直持续记录的（即，众议院大火死亡的25％是由于ho积）该患者人群的残疾尚不清楚。此外，导致老年残疾的因素具有高清的成年人，包括认知因素，尚未充分地浮出水面。新兴数据，包括我们小组的工作，建议在特定的认知领域定义很常见在整个HD的寿命中。该项目将检查高清对老年人的功能影响 - 具体来说，认知功能之间的关系，ho积症状严重程度和残疾。此外，我们将评估HD的遗传风险概况，以及HD与也影响残疾的医学和精神病合并症。为了实现我们的目标，我们将将面对面的临床，神经心理学和医学脆弱评估与独特流行病学资源，在线大脑健康注册表（BHR; www.brainhealthregistry.org）。 BHR旨在加速参与衰老和衰老的临床试验相关疾病，在三年内已注册了54,000多名主题有兴趣参加每月1000名新参与者进行正在进行的研究。将近一半（47％）的参与者年龄在60岁以上。参与者的特征是关注精神病，神经系统，家庭和病史，并纵向遵循每六个月重新评估一次。确定与残疾有关的因素高清将告知在此脆弱的情况下开发更有效的治疗干预措施人口并为改善生活质量提供了巨大的希望。