Development and Neuroadaptations in Alcohol and Addiction

酒精和成瘾的发育和神经适应

• 批准号: 10166730
• 负责人: J. DAVID JENTSCH
• 金额: $ 25.59万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166730
• 关键词: Alcohols; Development; addiction; neuroadaptation

ABSTRACT The goal of this proposal is to support a new pre- and post-doctoral training program in the area of development and neuroadaptations in alcohol and addictions (DNA2). Given increasing recognition that alcoholism and other substance use disorders have roots established in development, the proposed training grant will provide the next generation of addiction researchers with crucial training in the conceptual issues and methodological approaches for studying developmental neuroadaptations leading to abuse and addiction. Building on existing research strengths in this area exemplified by the Developmental Exposure Alcohol Research Center (DEARC) and anchored by historically strong graduate training programs in development, addictions and neuroadaptations within psychological sciences along with rapidly evolving programs in community science and public affairs, the DNA2 T32 provides the rich, cooperative intellectual environment conducive for highly successful research training, didactic education and mentorship for the proposed predoctoral (4/yr) and postdoctoral (2/yr) trainees. The training program emphasizes five key goals: (1) to actively seek and recruit a highly qualified and diverse group of pre- and post-doctoral trainees whose interest in and commitment to research in alcohol and addictions fits the laboratory(s) of one or more mentor-eligible faculty; (2) to provide individualized training experiences that foster expertise in state-of-the-art assessments, hypothesis formation, rigorous experimental design, data acquisition and analysis, and oral presentation and publication of results; (3) to assist trainees in generating preliminary data, novel hypotheses and specific aims and provide training in writing and grantsmanship for individual grant or F31/32 fellowship applications; (4) to create an individualized, multi-level research training environment that encourages both expertise and breadth in conceptual knowledge and technical capabilities and fosters translational considerations; and (5) to support the career/professional development of each trainee. To meet these goals, the T32 program will provide comprehensive interdisciplinary training through didactic coursework, trainee workshops, seminars/colloquia, journal and writing clubs, supervised research experiences, and participation in professional meetings and extra-university training opportunities. Methodological issues and techniques in alcohol and drug abuse research will be emphasized throughout the typical 2-year training period for each trainee, with a particular focus on training in developmental approaches, and rigorous attention to education in the responsible conduct of research, including means to enhance research reproducibility. This training program combines the expertise of faculty with established expertise in the alcohol field as well as in research with other drugs of abuse to capitalize on synergies across research programs and perspectives.

抽象的 该提案的目的是支持该领域的新的前后博士后培训计划 酒精和成瘾的发育和神经适应（DNA2）。考虑到越来越认识到 酒精中毒和其他物质使用障碍的源头是开发，拟议的培训 格兰特（Grant）将为下一代成瘾研究人员提供概念性问题和 研究发展性神经适应的方法学方法导致滥用和成瘾。 建立在这一领域的现有研究优势的基础上，以发育暴露酒精为例 研究中心（DEARC），并由历史强大的开发研究生培训计划锚定， 心理科学中的成瘾和神经照顾以及迅速发展的计划 社区科学与公共事务，DNA2 T32提供了丰富的合作智力环境 有利于拟议中的高度成功研究培训，教学教育和指导 术前（4年）和博士后（2/yr）受训者。培训计划强调了五个关键目标：（1） 积极寻求和招募一个高度合格和多样化的博士后学员，他们的兴趣 对酒精和成瘾研究的研究和承诺符合一个或多个符合指导者资格的实验室 学院; （2）提供个性化的培训经验，以促进最先进评估方面的专业知识， 假设形成，严格的实验设计，数据获取和分析以及口头表现以及 结果发布； （3）帮助受训者生成初步数据，新颖的假设和特定目的 并为个人赠款或F31/32奖学金申请提供写作和授予技巧的培训； （4）至 创建个性化的多层次研究培训环境，以鼓励专业知识和广度 在概念知识和技术能力以及促进翻译方面的注意事项中； （5）支持 每个学员的职业/专业发展。为了实现这些目标，T32计划将提供 通过教学课程，实习生研讨会，研讨会/校长，全面的跨学科培训， 期刊和写作俱乐部，监督研究经验以及参加专业会议和 外大学培训机会。酒精和药物滥用的方法论问题和技术 在整个典型的2年培训期间，每个学员都将强调研究，并具有特定的 专注于发展方法中的培训，并严格关注负责任行为的教育 研究，包括增强研究可重复性的方法。该培训计划结合了 具有既定专业知识的教师专业知识以及与其他药物的研究 滥用以利用研究计划和观点的协同作用。