Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment

试点 Y-AMBIENT：针对年轻非裔美国乳腺癌幸存者治疗中的生活质量干预

• 批准号: 10165670
• 负责人: Timiya S Nolan
• 金额: $ 17.81万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10165670
• 关键词: Address; Affect; African American; Age; Attention; Audiotape; Award; Breast Cancer Education; Breast Cancer Treatment; Breast Cancer survivor; Cancer Burden; Cancer Survivorship; Child; Chronic; Cognitive; Communication; Conflict (Psychology); Development; Discipline of Nursing; Discrimination; Disease; Early treatment; Education; Educational Intervention; Enrollment; Evidence based intervention; Face; Foundations; Future; Goals; Guidelines; Health; Health Personnel; Health Promotion; Health Services Accessibility; Image; Insurance; Intervention; Knowledge; Late Effects; Latina; Life; Malignant Neoplasms; Manuscripts; Measures; Mentors; Methods; Minority Groups; Modeling; Nurses; Ohio; Outcome; Participant; Patients; Perception; Personal Satisfaction; Policies; Population; Procedures; Process; Protocols documentation; Publishing; Quality of life; Race; Randomized; Randomized Controlled Trials; Recommendation; Recording of previous events; Reporting; Research; Resources; Sample Size; Scientist; Self Efficacy; Self Management; Social support; Socialization; Spirituality; Survivors; TFF1 gene; Techniques; Telephone; Testing; Time; Translating; Translations; Treatment Efficacy; Underrepresented Minority; Universities; Ursidae Family; Woman; Writing; acceptability and feasibility; anxiety reduction; arm; attentional control; base; biobehavior; career; career development; college; comorbidity; contextual factors; control trial; early onset; efficacy trial; evidence base; experience; follow-up; global health; health disparity; improved; low socioeconomic status; malignant breast neoplasm; post intervention; preference; primary outcome; professor; programs; psychologic; psychosocial; public health priorities; recruit; response; satisfaction; skills; social; social health determinants; stressor; survivorship; treatment as usual; two-arm study; willingness

Project Summary/Abstract Timiya S. Nolan is an Assistant Professor in the College of nursing at The Ohio State University. Dr. Nolan is responding to PAR-18-336 to obtain the skills, knowledge and mentored research experience that are essential for a career as a nurse scientist focusing on cancer survivorship health disparities research. Her long-term goal is to build an independent program of research that identifies contextual factors of quality of life (QOL) among young (18-44) breast cancer survivors from underrepresented minority groups and translates findings to the development, implementation, and dissemination/translation of multi-level QOL interventions and policy changes. The short-term goals for the award period include developing expertise in biobehavioral and environmental contributors to cancer and health outcomes (particularly QOL), scientific processes in the conduct of longitudinal intervention and observational trials, advanced quantitative methods, manuscripts writing and grantsmanship toward building a presence in her respective field among young and African American (AA) breast cancer survivors. Young AA survivors report poorer quality of life (QOL), and face more negative social determinants of health (e.g., low socioeconomic status, limited access to care, discrimination) than young White survivors. Yet, there are no published interventions that comprehensively address QOL (i.e., physical, psychological, social and spiritual well-being) in young AA survivors. This proposal is aimed at evaluating processes and preliminary outcomes of a targeted QOL intervention vs. control in young AA survivors in treatment for early (I-II) & late (III) stage breast cancer. Dr. Nolan adapted this Y-AMBIENT intervention from an existing evidence-based intervention using input from young AA survivors and healthcare providers. We will conduct a two-arm, pilot randomized controlled trial to evaluate feasibility, acceptability, and preliminary health-related outcomes of Y-AMBIENT (themed education, written materials, and videos) vs. an attention control (enhanced usual care). We will recruit 40 young AA survivors who have completed primary breast cancer treatment (n=20 per group and equal representation of those with a history of early and late stage breast cancer within). We will measure feasibility via study recruitment and retention (i.e., study enrollment and study contact completion) and protocol acceptability with satisfaction, usefulness, use of strategies via our Topical Concern and Strategy Sheet. We will triangulate qualitative and quantitative responses from each study contact to (a) identify participants’ perceptions of its acceptability, (b) willingness to participate in aspects of the protocol (participant burden), and (c) use of self-management strategies. At baseline, two-, and five-months, we will examine health-related outcomes (i.e., QOL, spiritual well-being, self- efficacy, and social support) within and between groups using descriptive and multiple-effects modeling techniques. Mentored research accomplished during the award period will lay the foundation for a large efficacy trial of Y-AMBIENT and future identification of other modifiable factors to address with interventions.

项目摘要/摘要 Timiya S. Nolan是俄亥俄州立大学护理学院的助理教授。诺兰博士是 响应Par-18-336，以获得必不可少的技能，知识和指导研究经验 作为护士科学家的职业，专注于癌症生存差异研究。她的长期目标 是建立一个独立的研究计划，以确定生活质量的上下文因素（QOL） Young（18-44）乳腺癌的存活来自代表性不足的少数群体，并将发现转化为 多层QOL干预和政策的开发，实施和传播/翻译 更改。奖励期的短期目标包括发展生物行为方面的专业知识 癌症和健康结果的环境贡献者（部分是QoL），科学过程 进行纵向干预和观察试验，高级定量方法，手稿 写作和赠款技巧，以在年轻人和非洲的相对领域建立存在 美国（AA）乳腺癌存活。年轻的AA生存报告的生活质量较差（QOL），面对更多 负面的社会决定者（例如，社会经济状况低，获得护理的机会有限，歧视） 比年轻的白人幸存者。但是，没有公开的干预措施可以全面解决QoL（即 年轻的AA生存中的身体，心理，社会和精神健康。该提议的目的是 评估目标QOL干预与年轻AA的控制的过程和初步结果 早期（I-II）和晚期（III）阶段乳腺癌治疗的幸存者。诺兰博士改编了这个Y-Ambient 使用年轻的AA表面和医疗保健的意见，从现有的基于证据的干预中进行干预 提供者。我们将进行一项两臂的飞行员随机对照试验，以评估可行性，可接受性和 Y-Ambient（主题教育，书面材料和视频）的初步与健康相关的结果 注意力控制（增强了通常的护理）。我们将招募40名年轻的AA冲浪者 乳腺癌治疗（每组n = 20 n = 20 内部乳腺癌）。我们将通过研究招聘和保留率衡量可行性（即研究 注册和研究联系完成）和协议可接受性，有用性，使用 通过我们的局部关注和策略表的策略。我们将进行三角定性和定量 每次研究的回答与（a）确定参与者对其可接受性的看法，（b）愿意 参与协议的各个方面（参与者伯恩），以及（c）使用自我管理策略。 基线，两个月和五个月，我们将检查与健康相关的结果（即QOL，精神福祉，自我自我 效率和社会支持）在组内和之间使用描述性和多效应建模 技术。在奖励期间完成的指导研究将为大型大型研究奠定基础 Y am-ambient和未来对其他可修改因素识别的功效试验，以解决干预措施。