Alliance NCORP Research Base

联盟NCORP研究基地

基本信息

批准号：
10172168
负责人：
Monica M Bertagnolli
金额：
$ 767.3万
依托单位：
ALLIANCE NCTN FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10172168
关键词：
Academic Medical Centers Address Advocate Aging Area Attention Behavior Blood Cancer Burden Cancer Patient Cancer Research Project Caregivers Clinical Clinical Research Clinical Trials Collaborations Collection Committee Membership Communities Community Clinical Oncology Program Companions Data Data Reporting Databases Development Diagnosis Disease Education Elderly Functional disorder Funding Funding Opportunities Grant Health Human Incidence Intervention Intervention Studies Maintenance Malignant Neoplasms Manuscripts Mentors Mentorship Metastatic Neoplasm to the Bone Metastatic malignant neoplasm to brain Minority Mission Monitor Morbidity - disease rate National Cancer Institute National Clinical Trials Network Natural History Nausea and Vomiting Oncologist Oncology Outcome Outcome Assessment Outcomes Research Parents Patient Outcomes Assessments Patients Pharmacologic Substance Population Prevalence Prevention Publishing Quality of life Research Research Methodology Research Personnel Research Priority Risk Site Source Symptoms Technology Tissue Sample Toxic effect Training Translational Research Tumor Tissue United States Work base cancer care cancer clinical trial cancer health disparity cancer prevention cancer risk cancer therapy care delivery chemotherapy clinically relevant clinically significant curative treatments data sharing disparity reduction experience financial toxicity health disparity high risk improved innovation mortality multidisciplinary next generation novel older patient premalignant prevent programs reduce symptoms repository skeletal-related events survivorship treatment trial underserved minority

项目摘要

Alliance NCORP Research Base Project Summary/Abstract The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published 148 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI-funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly-funded research network.

联盟NCORP研究基地项目概要/摘要肿瘤学临床试验联盟（联盟）是五个国家临床试验网络团体之一，作为联盟 NCI 社区肿瘤学研究计划 (NCORP) 的上级组织研究基地（Alliance NCORP）。 Alliance NCORP 进行介入和观察临床。和转化研究以及数据库研究——所有这些都解决了与此外，NCORP 联盟还开展癌症预防、症状控制和癌症护理服务。癌症治疗试验中的临床重要生活质量研究具有特殊意义。重点关注有癌症风险或诊断出患有癌症的少数族裔、服务不足和老年患者，并建立与 NCORP 社区网站和少数群体/服务不足的社区网站建立牢固的合作关系。联盟 NCORP 委员会成员包括来自社区和社区的丰富代表学术医疗中心以及患者权益倡导者，从而产生与癌症相关的研究成果联盟 NCORP 还强调对初级患者的指导和培训。在过去的资助周期中，即自 2014 年 8 月以来，联盟 NCORP 已发布了 148 项这项工作包括诸如以下领域的改变实践的研究。预防化疗引起的恶心和呕吐，预防骨骼相关事件骨转移、脑转移的治疗以及患者报告结果的整合联盟 NCORP 开展需要收集的转化研究。肿瘤组织、癌前组织样本、血液和其他人类生物样本；并共享数据和用于汇总分析和其他科学合作的生物样本这些生物样本创建了一个从机制的角度理解临床观察的宝贵资料库。 NCORP 还与其他 NCI 资助的研究人员和财团以及研究人员通过非 NCI 来源支持这项改变实践的研究和科学。联盟 NCORP 回答的问题为临床和临床研究提供了有意义和创新的贡献转化肿瘤学，只能在公共资助的研究网络内进行。