Developmental Determinants of Cardiovascular Disease

心血管疾病的发育决定因素

• 批准号: 10164843
• 负责人: H Scott Baldwin
• 金额: $ 34.95万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164843
• 关键词: Cardiovascular Diseases; Development

This is the first renewal of the T32 application from Division of Pediatric Cardiology, Vanderbilt University School of Medicine. By advancing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology, we will provide a unique training environment that will foster development of academic pediatric cardiologists. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of cardiovascular pathology after birth. In addition to trainees in the Pediatric Cardiology, clinical or Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. We are requesting continued support for 3 trainees / year for two years for a total of 6 trainees / year for a five year period. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused, mentored, laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will be identified from the pool of applicants applying for a pediatric cardiology fellowship (112 applicants for 3 positions in 2017) as well as from talented clinical and post-doctoral fellows throughout Vanderbilt University. During a first clinical year of pediatric cardiology fellowship (PGY-4) the candidates will be matched with mentors and together, they will decide upon a research project. During the second and third years of a four year fellowship, trainees will carry out a mentored research project. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. This grant will provide support for the second and third years of protected research training. The Department of Pediatrics is committed to complete support of fellows during the first and fourth years as well as supplementing support provided by this grant in years two and three. Using the unique strengths of Vanderbilt University in the areas of cardiac development and regeneration, myocardial biology, pulmonary biology and pulmonary hypertension, cardiovascular genetics and pharmacogenomics, vascular biology and atherosclerosis, as well as cardiovascular outcomes based research and bioinformatics, the program will help train the next generation of physician scientists focused on pediatric cardiovascular disease.

这是范德比尔特大学儿科心脏病学系的T32申请的第一次续签 医学院。通过推进一项将正式培训整合在发展研究中的计划 心血管疾病的心血管疾病决定因素，并在儿科心脏病学领域进行临床培训，我们将提供独特的 培训环境将促进学术儿科心脏病学家的发展。该培训计划将 不仅关注先天性心脏病的分子和遗传病因，而且还将强调 产前和产后发育在定义出生后心血管病理的表现方面的影响。 除了儿科心脏病学的学员，临床或博士学位。博士后研究员 对调查心血管疾病的发展机制的兴趣将有资格 支持。我们要求持续支持3名学员 /年，为期两年，总计6名受训者 /年 五年。该计划将为学员提供一个独特的机会研究 心血管病理的个体发育中的正常发育过程，在儿童时期或 成年。该程序将由优化的两条曲目组成，以追求（1）基本的准备工作 科学调查或（2）临床或转化研究。专注，指导的实验室经验 有针对性的教学互动将被量身定制，以满足从事更基础科学职业的人的需求。 对于从事临床或转化医学职业的学员，范德比尔特临床科学硕士 调查（MSCI）计划将是培训计划不可或缺的一部分。候选人将从 申请儿科心脏病学奖学金的申请人库（2017年有112名申请人为3个职位） 以及整个范德比尔特大学的才华横溢的临床和博士后研究员。在第一次临床期间 小儿心脏病学年奖学金（PGY-4）候选人将与导师相匹配，他们在一起 将决定一个研究项目。在四年奖学金的第二年和第三年中，学员将 执行指导的研究项目。在第四年，学员将完成临床培训 在子规定的高级培训以及继续研究和提交K08或 K23申请。该赠款将为受保护的研究培训的第二年和第三年提供支持。 儿科部致力于在第一和第四年全部支持研究员 还补充了这笔赠款在第二和三年中提供的支持。利用独特的优势 范德比尔特大学在心脏发展和再生，心肌生物学，肺部 生物学和肺高血压，心血管遗传学和药物基因组学，血管生物学和 动脉粥样硬化以及基于心血管结局的研究和生物信息学，该计划将有助于 培训下一代的医师科学家，专注于小儿心血管疾病。