Functional Genomics Training Program (FGTP)

功能基因组学培训计划（FGTP）

• 批准号: 10164811
• 负责人: ANN HARRIS
• 金额: $ 19.51万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10164811
• 关键词: Training Programs; functional genomics

PROJECT SUMMARY The goal of this new Functional Genomics Training Program (FGTP) is to provide predoctoral students with an integrative training that encompasses basic research, bioinformatics, clinical genetics, and ethics. Genomics has become the basis for the study of human genetic disease, and we see a critical need for a formalized training program, especially as interest in human genomics and precision medicine has grown and continues to grow among students and the applicant pool at CWRU. Through this integrative model, we aim to empower students with a specialized skillset critical for ushering in and shaping the new era of precision medicine in both an efficient and responsible manner. To accomplish this training goal, we assembled a well-funded cohesive group of mentors with relevant genomics expertise in the following five key focus areas: (1) Mechanisms and Treatment of Human Genetic Disease, (2) Chromatin, Regulatory Elements, and RNA, (3) Bioinformatics and Biostatistics, (4) Cancer Genetics, (5) Clinical Genetics, Genetic Counseling and Ethics. Training will include coursework and hands on training in functional genomics and bioinformatics, along with clinically oriented training in which students shadow clinicians, observe genetic counseling sessions, and follow clinical diagnostic cases. Furthermore, as it is imperative to ensure that we train an ethically and socially responsible next generation of biomedical scientists, our training model will also incorporate ethics and the potential societal implications of functional genomics research, including genome editing. CWRU, with two key Departments that recently procured large reinvestments (Genetics and Genome Sciences, Population and Quantitative Health Sciences), a Clinical Center for Human Genetics, a Genetic Counseling Program, Genetics Diagnostic Labs, and two major hospitals (University Hospitals and the Cleveland Clinic), all located within a 1 mile radius, provides an ideal training hub for our program. We believe that this new program will have a significant and sustained impact on graduate education at CWRU by serving as a vehicle for uniting functional genomics research across the University and greater Northeast Ohio.

项目摘要 这项新功能基因组学培训计划（FGTP）的目标是提供 主导学生接受综合培训，包括基础研究， 生物信息学，临床遗传学和伦理学。基因组学已成为研究的基础 人类遗传疾病，我们认为对正式培训计划的迫切需要 特别是随着对人类基因组学和精确医学的兴趣的增长并继续 在CWRU的学生和申请人池之间成长。通过这个综合模型， 我们旨在使学生能够以专门的技能为重要的技巧 精密医学的新时代以有效和负责任的方式。到 完成这个训练目标，我们通过 相关基因组学专业知识在以下五个关键重点领域中：（1）机制和 治疗人遗传疾病，（2）染色质，调节元件和RNA，（3） 生物信息学和生物统计学，（4）癌症遗传学，（5）临床遗传学，遗传学 咨询和道德。培训将包括课程工作和功能培训 基因组学和生物信息学，以及临床上的培训 影子临床医生，观察遗传咨询会议，然后遵循临床诊断 案例。此外，必须确保我们在道德和社会上训练 负责任的下一代生物医学科学家，我们的培训模型还将合并 伦理和功能基因组学研究的潜在社会意义，包括 基因组编辑。 CWRU，最近有两个主要部门 再投资（遗传学和基因组科学，人群和定量健康 科学），一个人类遗传学的临床中心，遗传咨询计划，遗传学 诊断实验室和两家主要医院（大学医院和克利夫兰诊所） 位于1英里半径内，为我们的计划提供了理想的培训中心。我们相信 这个新计划将对研究生教育产生重大和持续的影响 CWRU通过作为团结功能基因组学研究的工具 大学和大东北俄亥俄州。