Vanderbilt O'Brien Kidney Center

范德比尔特奥布莱恩肾脏中心

基本信息

批准号：
10163162
负责人：
RAYMOND C. HARRIS
金额：
$ 118.5万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2023-06-30
项目状态：
已结题

项目摘要

The mission of the Vanderbilt O'Brien Kidney Center (VOKC) is to advance research opportunities for kidney related research and promote effective interactions between basic scientists and clinical researchers in order to advance effective prevention and treatment of acute and chronic kidney disease and their complications. To accomplish its mission, the Vanderbilt O'Brien Kidney Center supports Biomedical Research Cores, Pilot and Feasibility Grants and a robust Educational Enrichment Program. There are three Biomedical Research Cores that provide services to investigators utilizing preclinical models of kidney injury: a Phenotyping and Pathophysiology Core, an Histology and Molecular Pathology Core and a Cell and Genome Engineering Core and a robust Clinical and Translation Core for investigators involved in translational and epidemiologic research. These Cores support kidney research that is conducted by 92 investigators at Vanderbilt. In addition, our goal in developing the VOKC is for it to serve as a national and international resource, and, as indicated in the description of the Biomedical Research Base, investigators at institutions in both the U.S. and abroad have utilized resources of the Biomedical Core; in addition, we have provided services to a number of pharmaceutical companies. During its previous funding period, the Center supported studies that have provided new insights into the pathogenesis and treatment of diabetic nephropathy, hypertension, acute kidney injury, glomerular and tubulointerstitial fibrosis and complications of chronic kidney disease.

范德比尔特奥布莱恩肾脏中心 (VOKC) 的使命是推进研究肾脏相关研究的机会并促进之间的有效互动基础科学家和临床研究人员，以推进有效的预防和治疗治疗急慢性肾脏疾病及其并发症。为实现其使命，范德比尔特奥布莱恩肾脏中心支持生物医学研究核心，试点和可行性补助金以及强大的教育丰富计划。有三个生物医学研究核心，为研究人员提供服务肾损伤的临床前模型：表型和病理生理学核心，组织学和分子病理学核心以及细胞和基因组工程核心和为参与翻译和翻译的研究人员提供强大的临床和翻译核心流行病学研究。这些核心支持由 92 人进行的肾脏研究范德比尔特大学的调查员。另外，我们开发VOKC的目标是让它服务于作为国家和国际资源，并且如描述中所示生物医学研究基地，美国和国外机构的研究人员利用生物医学核心的资源；此外，我们还为制药企业数量。在上一个资助期间，该中心支持为发病机制和治疗提供新见解的研究糖尿病肾病、高血压、急性肾损伤、肾小球肾小管间质纤维化和慢性肾脏疾病的并发症。

项目成果

期刊论文数量（38）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Development of a Patient Preference Survey for Wearable Kidney Replacement Therapy Devices.

开发可穿戴肾脏替代治疗设备的患者偏好调查。

DOI：
10.34067/kid.0001862022
发表时间：
2022
期刊：
Kidney360
影响因子：
0
作者：
Flythe,JenniferE;Forfang,Derek;Gedney,Nieltje;White,DavidM;Wilkie,Caroline;Cavanaugh,KerriL;Harris,RaymondC;Unruh,Mark;Squillaci,Grace;West,Melissa;Mansfield,Carol;Soloe,CindyS;Treiman,Katherine;Wood,Dallas;Hurst,FrankP;
通讯作者：

Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.

类二十烷酸途径的遗传变异与非小细胞肺癌 (NSCLC) 的生存相关。

DOI：
10.1371/journal.pone.0180471
发表时间：
2017
期刊：
PloS one
影响因子：
3.7
作者：
Sausville,LindsayN;Jones,CarissaC;Aldrich,MelindaC;Blot,WilliamJ;Pozzi,Ambra;Williams,ScottM
通讯作者：
Williams,ScottM

Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease.