Physical Activity and Preservation of Cognitive Function

体力活动和认知功能的保护

• 批准号: 10160748
• 负责人: Priya Palta
• 金额: $ 22.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10160748
• 关键词: Accelerometer; Activities of Daily Living; Address; Aerobic Exercise; African American; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s Disease Pathway; Alzheimer' s disease risk; Area; Atherosclerosis Risk in Communities; Award; Behavior; Biochemical; Biochemical Pathway; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Cardiovascular Diseases; Career Choice; Clinical; Clinical Research; Cognition; Cognitive; Cognitive aging; Communities; Competence; Complement; Data; Dementia; Dependence; Doctor of Philosophy; Educational Curriculum; Educational process of instructing; Elderly; Ensure; Epidemiologist; Epidemiology; Geriatrics; Goals; Grant; Health Care Costs; Hippocampus (Brain); Hispanic Community Health Study/Study of Latinos; Impaired cognition; Impairment; Incidence; Individual; Insulin-Like Growth Factor I; Interdisciplinary Study; Intervention; Lead; Life Style; Link; Longitudinal trends; Measurement; Measures; Medicine; Mentors; Modality; Neural Pathways; Neurocognition; Neurocognitive; Neurology; Neuronal Plasticity; Neurosciences; North Carolina; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Phase; Physical activity; Population; Population Distributions; Population Research; Population Sciences; Population Study; Postdoctoral Fellow; Race; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Risk Factors; Role; Sampling; Science; Scientist; Structure; Supervision; Testing; Training; United States National Institutes of Health; Universities; Woman; Work; Writing; active lifestyle; activity marker; adjudicate; age related; aging population; base; brain morphology; cardiovascular disorder epidemiology; cardiovascular disorder risk; career; career development; cognitive function; cognitive testing; cohort; comorbidity; design; disability; distinguished professor; gray matter; hands-on learning; innovation; men; middle age; mild cognitive impairment; modifiable behavior; modifiable risk; multidisciplinary; neurogenesis; neuroimaging; neuroimaging marker; neurotrophic factor; novel; population based; population health; preservation; prevent; professor; programs; prospective; protective behavior; relating to nervous system; release factor; response; skills; stem; total energy expenditure

PROJECT SUMMARY/ ABSTRACT This is a NIH Pathway to Independence Award (K99/R00) application intended to promote the career of Dr. Priya Palta, PhD, a postdoctoral fellow at the University of North Carolina at Chapel Hill, to a path of independent research. Dr. Palta is a trained epidemiologist with a multidisciplinary record of research in the epidemiology of cardiovascular disease (CVD), aging, and CVD risk factors for cognitive decline and dementia. Her goal is to build on these skills through focused training in neuroscience to become an independent scientist at the interface of neuroscience and population sciences, for innovative work on modifiable targets that influence pathways associated with age-related cognitive decline. The topical areas of the proposed training and subsequent research are physical activity, age-related cognitive decline, neuroimaging, and neurotrophic factors reported to link physical activity with increased neuroplasticity. K99 Career development aim: Obtain transdisciplinary competencies in the biochemical and neural pathways that underlie cognitive function, including neurotrophic biomarkers and neuroimaging modalities through a didactic and experiential curriculum complemented by a novel prospective population-based study. These activities will be supervised by lead mentor Dr. Gerardo Heiss, MD PhD, Kenan Distinguished Professor of Epidemiology and co-mentors Dr. Kelly Evenson, PhD, Research Professor of Epidemiology, and Dr. Thomas Mosley, PhD, Professor of Medicine (Geriatrics) and Neurology. A team of collaborators with complementary expertise will supplement Dr. Palta's training in specific areas. The team of mentors and collaborators is fully committed to assisting Dr. Palta reach her research training and career development goals and to ensure her successful transition to independent researcher. Post-mentored R00 phase: Dr. Palta will apply the K99 competencies to develop an innovative R00 project nested in the cohort of the ongoing Atherosclerosis Risk in Communities (ARIC) Study. For this, physical activity over 23 years and neurotrophic markers (BDNF and IGF-1) measured on the ARIC participants will be related to repeat cognitive assessments, gray matter hippocampal volumes, and adjudicated mild cognitive impairment (MCI) and Alzheimer's disease (AD). Anticipated results: Through this Pathway to Independence Award, Dr. Palta will acquire (1) in-depth multidisciplinary training in the measurement, analysis and interpretation of (a) neurotrophic biomarkers and (b) neuroimaging outcomes for their application in population-based studies and (2) apply these new competencies to an innovative research question on the biochemical and neural links between physical activity and neurocognitive outcomes. This proposal will contribute novel science in the (1) critical assessment of the role of midlife physical activity in delaying cognitive impairment, (2) on the population distribution of BDNF and IGF-1 and its associations with physical activity and neurocognitive outcomes, and (3) targets for community-based lifestyle and physical activity programs to impact cognitive aging.

项目摘要/摘要 这是NIH独立奖（K99/R00）申请，旨在促进博士的职业生涯。 Priya Palta博士，北卡罗来纳大学教堂山分校的博士后研究员， 独立研究。 Palta博士是一位受过训练的流行病学家，在研究中具有多学科的研究记录 认知下降和痴呆的心血管疾病（CVD），衰老和CVD风险因素的流行病学。 她的目标是通过专注于神经科学的培训来建立这些技能，成为独立 神经科学和人口科学界面的科学家，用于修改目标的创新工作 这会影响与年龄相关的认知下降相关的途径。拟议的局部区域 培训和随后的研究是体育活动，与年龄相关的认知能力下降，神经影像学和 据报道，神经营养因素将身体活动与神经塑性增加联系起来。 K99职业发展 目的：在认知基础的生化和神经途径中获得跨学科的能力 功能，包括神经营养生物标志物和通过教学和体验的神经影像学方式 课程与一项新型的前瞻性基于人群的研究相辅相成。这些活动将受到监督 首席导师Gerardo Heiss博士，医学博士学位，Kenan杰出的流行病学教授兼联席会员 凯利·埃文森（Kelly Evenson）博士，流行病学研究教授和托马斯·莫斯利（Thomas Mosley）博士 医学（老年医学）和神经病学。具有补充专业知识的合作者团队将补充博士。 帕尔塔在特定领域的培训。导师和合作者团队完全致力于协助博士。 Palta达到了她的研究培训和职业发展目标，并确保她成功过渡到 独立研究员。现金后的R00阶段：Palta博士将应用K99的能力来开发 创新的R00项目嵌套在社区正在进行的动脉粥样硬化风险（ARIC）研究中。 为此，在ARIC上测量的23年的体育活动以及神经营养标记（BDNF和IGF-1） 参与者将与重复的认知评估，灰质海马体积和 裁定的轻度认知障碍（MCI）和阿尔茨海默氏病（AD）。预期结果：通过 获得独立奖的途径，帕尔塔博士将获得（1）深入的多学科培训 （a）神经营养生物标志物和（b）神经成像结果的测量，分析和解释 它们在基于人群的研究中的应用，（2）将这些新能力应用于创新研究 关于体育活动与神经认知结果之间生化和神经联系的问题。这 提案将在（1）对中年体育活动中的作用的批判性评估中贡献新科学 延迟认知障碍，（2）关于BDNF和IGF-1的种群分布及其与其与其与其关联的关联 体育活动和神经认知结果，以及（3）基于社区生活方式和身体的目标 影响认知衰老的活动计划。