Administrative Core

行政核心

基本信息

批准号：
10159860
负责人：
Betty Diamond
金额：
$ 7.99万
依托单位：
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10159860
关键词：
Adherence Advisory Committees Autoantibodies Autoimmunity B-Lymphocytes Biometry Blood Cells Clinical Clinical Data Clinical Investigator Clinical Trials Collaborations Collection Communities Consultations Data Diamond Ensure Goals Immunization Individual Inflammatory Arthritis Institution Institutional Review Boards Logistics Lupus Manuscripts Pathogenesis Pathway interactions Patient Recruitments Patient Selection Patients Pilot Projects Plasma Cells Principal Investigator Production Prognosis Progress Reports Protocols documentation Regulation Research Research Personnel Research Project Grants Rheumatology Role Sampling Schedule Specimen Systemic Lupus Erythematosus TNF gene Technology Tetanus Toxoid Time biobank clinical center clinical infrastructure clinical research site cohesion cohort cross reactivity data management data repository experience individual patient influenza virus vaccine inhibitor/antagonist meetings member novel therapeutics organizational structure recruit therapeutic target translational study

项目摘要

Administrative Core Project Summary The overall goal of our Autoimmunity Center of Excellence proposal is to investigate mechanisms for the production of autoantibodies that contribute to the pathogenesis of SLE. Three individual projects will examine basic questions related to initial induction of autoantibodies, the B cells that produce them, cross-reactivity and regulation of autoantibody producing B cells in patients with SLE (Principal and Pilot Projects) and in patients with inflammatory arthritis that develop lupus-related autoimmunity induced by TNF inhibitors (Collaborative Project). The Administrative Core will be central to the functioning of our ACE by providing budgetary and financial oversight, by managing interactions with the clinical investigators who will be recruiting patients for the proposed translational studies, by providing biostatistical oversight and by providing logistical support to facilitate scientific interactions within the Feinstein ACE, with collaborators and with other ACE members. The Core will be co- directed by Drs Anne Davidson and Betty Diamond who have vast experience with collaborative studies and will have complementary roles in managing interactions with collaborators. In addition, the Administrative Core will be supported by an established clinical infrastructure that includes a large patient pool, well-established patient cohorts, expert clinical collaborators, IRB approved protocols for data and blood collection, an experienced biostatistics collaborator and appropriate scientific technology. The close existing relationships between all the investigators and collaborators and with our long time administrative staff should ensure smooth functioning of the Core and successful implementation of all projects.

行政核心项目概要我们的自身免疫卓越中心提案的总体目标是调查导致 SLE 发病机制的自身抗体的产生机制。三个单独的项目将研究与初始诱导相关的基本问题自身抗体、产生它们的 B 细胞、自身抗体的交叉反应性和调节在 SLE 患者（主要和试点项目）和患有以下疾病的患者中产生 B 细胞 TNF 抑制剂诱导产生狼疮相关自身免疫的炎症性关节炎（合作项目）。行政核心将成为我们 ACE 运作的核心通过管理与临床的互动来提供预算和财务监督研究人员将招募患者进行拟议的转化研究，通过提供生物统计监督并提供后勤支持以促进内部科学互动 Feinstein ACE 与合作者以及其他 ACE 成员。核心将共同由 Anne Davidson 和 Betty Diamond 博士指导，他们在协作方面拥有丰富的经验研究并将在管理与合作者的互动方面发挥互补作用。在此外，行政核心将得到已建立的临床基础设施的支持，包括庞大的患者库、完善的患者队列、专家临床合作者、IRB 批准的数据和血液采集方案，经验丰富的生物统计学合作者和适当的科学技术。所有调查人员之间现有的密切关系和合作者以及我们的长期行政人员应确保顺利运作核心并成功实施所有项目。