Identifying Markers of Chronic Pain Development in Alcoholism

识别酗酒者慢性疼痛发展的标志

• 批准号: 10160727
• 负责人: Nasim Maleki
• 金额: $ 18.31万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-10 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10160727
• 关键词: Acute; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Analgesics; Anxiety; Brain; Brain Stem; Characteristics; Chronic; Data; Databases; Deterioration; Development; Diffusion; Disease; Down-Regulation; Early Diagnosis; Functional disorder; Heavy Drinking; Hippocampus (Brain); Hyperalgesia; Impairment; Individual; Interdisciplinary Study; Intervention; Lead; Link; Major Depressive Disorder; Mediating; Mental Depression; Mentored Research Scientist Development Award; Mentorship; Modeling; Motivation; Neural Pathways; Neurosciences; Nociception; Pain; Pain Research; Pain Threshold; Pathway interactions; Patients; Pattern; Play; Predictive Factor; Prefrontal Cortex; Process; Recording of previous events; Relapse; Reporting; Research; Rewards; Risk; Risk Factors; Role; Sensory; Spinal Cord; Statistical Models; Stimulus; Stress; Structure; Symptoms; Syndrome; System; Testing; Training; Up-Regulation; Woman; addiction; alcohol effect; alcohol relapse; alcohol risk; alcohol use disorder; alcohol use initiation; allodynia; base; career development; central sensitization; chronic alcohol ingestion; chronic back pain; chronic pain; chronic painful condition; cohort; cross disciplinary program; depressive symptoms; drinking; experience; insight; interdisciplinary approach; member; men; neuroadaptation; neuroimaging; neuropsychiatry; non-alcoholic; pain chronification; pain perception; pain processing; predictive marker; predictive modeling; problem drinker; relating to nervous system; response; sex; stress symptom

Summary This is an application for a Mentored Research Scientist Development Award (K01) to support the career development efforts of Dr. Nasim Maleki, including enhanced training in an integrated cross-disciplinary program consisting of in-depth experience in alcoholism neuroscience and pathophysiology under the mentorship of Dr. Marlene Oscar Berman, an expert at the forefront of research on alcohol abuse disorder (AUD), and a team of leading experts in alcoholism, pain, neuroimaging, and statistical modeling. The proposed research is an interdisciplinary study that would bridge AUD research with pain research and as such, allows insights into alcoholism as a risk factor for development of chronic pain disorders, and vice versa. Dr. Maleki aims to leverage neuroimaging and neuropsychiatric data from a large cohort of abstinent long-term alcoholic men and women, to develop retroactive insights and predictive models for chronic pain. Aim 1 seeks to determine whether AUD is associated with damage to the descending pain modulatory network (DPMN) pathways. Aim 2 is to gather further insights into potential abnormalities in the DPMN associated with AUD by performing quantitative sensory testing in AUD patients. Finally, Aim 3 will determine whether presence of depressive or stress symptoms are predictive of chronic pain development in AUD. As chronic pain syndromes have the propensity to trigger the risk of re-initiation of alcohol abuse in abstinent alcoholics, it is important to: (a) characterize pain related abnormalities associated with AUD; (b) understand neural links between AUD and chronic pain; and (c) ultimately identify markers that predict the risk of development of chronic pain in abstinent alcoholics. The findings should allow early detection of AUD patients at risk for developing chronic pain conditions, and earlier start of interventional approaches to reduce the risk of consequent alcohol abuse or relapse.

概括 这是指导研究科学家发展奖（K01）来支持职业的申请 Nasim Maleki博士的开发工作，包括在综合跨学科的增强培训 在酒精中毒神经科学和病理生理学下的深入经验的计划 玛琳·奥斯卡·伯曼（Marlene Oscar Berman）博士的指导，酗酒障碍研究最前沿的专家 （AUD），以及酗酒，疼痛，神经影像和统计建模领域领先的专家团队。提议 研究是一项跨学科的研究 洞察酒精中毒是慢性疼痛障碍发展的危险因素，反之亦然。 Maleki博士 旨在利用大量戒酒的长期酒精饮料的神经影像学和神经精神病数据 男性和女人，为慢性疼痛发展追溯见解和预测模型。目标1寻求 确定AUD是否与降低疼痛调节网络（DPMN）损坏有关 途径。 AIM 2是收集对与AUD相关的DPMN潜在异常的进一步见解 在AUD患者中进行定量感觉测试。最后，AIM 3将确定是否存在 抑郁症或压力症状可以预测AUD慢性疼痛的发展。作为慢性疼痛综合征 有倾向于引发戒酒中滥用酒精滥用的风险，重要的是： （a）表征与AUD相关的疼痛异常； （b）了解AUD和 慢性疼痛； （c）最终确定预测禁忌慢性疼痛风险的标记 酗酒者。这些发现应允许早期发现有慢性疼痛风险的AUD患者 条件，以及提前开始干预方法，以降低导致酒精滥用的风险或 复发。