1/3 Alcohol Research Consortium in HIV - Administrative Core (ARCH-AC)

1/3 HIV 酒精研究联盟 - 行政核心 (ARCH-AC)

基本信息

批准号：
10161321
负责人：
GEETANJALI CHANDER
金额：
$ 11.24万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-15 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10161321
关键词：
2019-nCoV Adherence Admission activity Adult Respiratory Distress Syndrome Alcohol consumption Alcohols Biological Markers COVID-19 Caring Cells Cessation of life Characteristics Clinical Cognitive Therapy Collection Computerized Medical Record Computers Counseling Data Data Analyses Data Collection Development Drug usage Economics Equipment Family Frequencies Funding Future Goals HIV Health Health behavior Heavy Drinking Home environment Hospitalization Impairment Infection Inflammatory Inpatients Internet Intervention Intervention Studies Location Malnutrition Mental Health Modeling Motivation Online Systems Outcome Outpatients Participant Patient Outcomes Assessments Patient Self-Report Patients Pattern Persons Pneumonia Positioning Attribute Predisposition Questionnaires Race Recording of previous events Reporting Research Risk Risk Factors Sales Secondary to Sepsis Severities Site Smoking Social Distance Stress Surveys Symptoms System Testing Time Tobacco Transportation Treatment outcome United States Viral Virus Diseases Wages Woman alcohol intervention alcohol misuse alcohol research alcohol use disorder anxiety symptoms binge drinking brief alcohol intervention brief intervention comorbidity depressive symptoms drinking epidemiology study follow-up food shortage hazardous drinking health care availability health disparity high risk high risk drinking improved interest mortality pandemic disease perceived stress racial and ethnic disparities response secondary infection sex stressor telehealth

项目摘要

This supplemental funding application for the Alcohol Research Consortium on HIV (ARCH) seeks to add COVID-19 related aims to our existing alcohol and HIV epidemiologic and intervention research. This proposal capitalizes on the strengths of the CFAR Network of Integrated Clinical Systems (CNICS), which include systematic, on-going collection of patient reported outcomes (PROs) at regular intervals as well as inpatient and outpatient electronic medical record (EMR) abstraction. First, using data from all active CNICS patients (N > 13,000), we will examine associations between alcohol use prior to and during the SARS-CoV-2 pandemic with rates of SARS-CoV-2 infection, and COVID-19-related hospitalizations, hospitalization duration, ICU admissions, and mortality. Second, in a subset of hazardous drinkers (N=100/site across 6 sites), we will implement a COVID-19 alcohol survey to capture longitudinal data (4 surveys over 12 – 18 months) on quantity/frequency of alcohol consumption, drinking locations and partners, as well as motivations for drinking. The survey also will assess perceived personal and family threat from SARS-CoV-2, compliance with social distancing and stay-at-home orders, COVID-19 specific stressors (e.g., reduced wages, reduced/no childcare, food shortage, transportation, access to health care for ongoing health problems), and levels of perceived stress. We will examine changes in alcohol use characteristics during and after the SARS-CoV-2 pandemic as a function of pre-pandemic alcohol use patterns, depressive and anxiety symptom severity, perceived stress and compliance with social distancing and stay-at- home orders. Third, we will study the impact of changes in alcohol use patterns on HIV treatment outcomes. We will validate drinking self-report using the alcohol biomarker PEth in a subsample of survey participants (N=40/site across 6 sites). Finally, survey participants will rate their interest in telehealth alcohol counseling and provide information on availability of equipment and internet access for implementation. Findings on COVID-19 related changes in drinking characteristics and patient interest in telehealth care models will position us to effectively implement remote counseling models for alcohol interventions in the future.

这是针对艾滋病毒酒精研究联盟 (ARCH) 的补充资金申请寻求将与 COVID-19 相关的目标添加到我们现有的酒精和 HIV 流行病学和该提案利用了 CFAR 网络的优势。综合临床系统 (CNICS)，包括系统性、持续的患者收集定期报告结果 (PRO) 以及住院和门诊电子版首先，使用所有活跃 CNICS 患者的数据 (N > 13,000），我们将研究 SARS-CoV-2 之前和期间饮酒之间的关联 SARS-CoV-2 感染率和与 COVID-19 相关的住院率的大流行，其次，是危险人群的住院时间、ICU 入院率和死亡率。饮酒者（N = 100/地点，跨 6 个地点），我们将实施一项 COVID-19 酒精调查，以捕获关于饮酒数量/频率的纵向数据（12 – 18 个月内的 4 次调查），该调查还将评估饮酒地点和伴侣以及饮酒动机。感知到 SARS-CoV-2 带来的个人和家庭威胁、遵守社交距离和居家令、COVID-19 特定压力源（例如工资减少、减少/不提供托儿服务、粮食短缺、交通运输、针对持续健康问题获得医疗保健的机会）以及我们将检查饮酒期间和之后的酒精使用特征的变化。 SARS-CoV-2 大流行与大流行前的饮酒模式、抑郁和抑郁有关焦虑症状的严重程度、感知的压力以及对社交距离和呆在家里的遵守情况第三，我们将研究饮酒模式的变化对艾滋病毒的影响。我们将使用酒精生物标志物 PEth 来验证饮酒自我报告。调查参与者的子样本（N=40/6 个地点的地点）最后，调查参与者将进行评分。他们对远程健康酒精咨询感兴趣并提供有关可用性的信息有关实施的设备和互联网接入的调查结果。饮酒特征和患者对远程医疗保健模式的兴趣将使我们能够未来实施有效的酒精干预远程咨询模式。