Administrative Supplement to The When to Worry about Language Study (W2W-L)

何时担心语言学习 (W2W-L) 的行政补充

基本信息

批准号：
10162280
负责人：
Elizabeth Spencer Norton
金额：
$ 19.71万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-03-05 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10162280
关键词：
Address Administrative Supplement Adverse effects Affect African American Age Algorithms Behavioral Biological Markers Buffers COVID-19 COVID-19 pandemic Caregivers Child Child Language Child Rearing Clinical Communities Custom Data Data Collection Development Early Intervention Early identification Electroencephalography Environment Family Family member Foundations Funding Goals Gold Hispanics Home environment Human Subject Research Illinois Impairment Individual Infant Institutes Interruption Intervention Language Language Delays Language Development Language Disorders Life Linguistics Machine Learning Measures Mediating Mental Health Methods Modeling Nursery Schools Outcome Parent-Child Relations Parents Participant Pattern Pediatric Hospitals Personal Satisfaction Persons Process Protocols documentation Public Health Race Research Activity Resource Allocation Risk Risk Assessment Sampling Siblings Speech Sound Stress Sum Support System Surveys Testing Time Toddler Transact Translations United States National Institutes of Health Validation Variant Visit base clinical practice cohort coronavirus disease design experience high risk innovation language impairment negative affect novel pandemic disease predictive modeling prevent protective effect recruit relating to nervous system sex social standard measure stress reduction translational approach tv watching visual tracking word learning

项目摘要

PROJECT SUMMARY – Original Submission Primary language impairment (PLI) begins early in life and affects 6-8% of children. Although language intervention is maximally effective the earlier it is delivered, normative variation in language acquisition across toddlerhood (here 24-36 months) impedes accurate identification of PLI prior to late preschool age. The proposed study introduces a novel, theoretically- grounded, neurodevelopmental framework designed to generate a sensitive and specific model to identify PLI as early as possible. Our developmentally- sensitive, translational approach introduces multiple innovations including: (1) characterizing the developmental patterning of toddler emergent language beginning at 24 mos. using state-of-the-art methods, within a large community sample; (2) incorporating EEG/ERP neural biomarkers of language into PLI risk assessment; (3) using a novel paradigm to assess the protective effects of both behavioral and neural synchronization within parent-child language transactions; and (4) consideration of irritability, a robust developmental marker of early mental health risk, to enhance identification of those language delayed toddlers at highest risk for persistence. For the proposed When to Worry about Language Study (W2W-L), we capitalize on our funded study of 350 infants (50% irritable and 50% non-irritable) (R01MH107652, Wakschlag, PI) and enrich it via recruitment of a sub-sample of 200 late talking toddlers. This will yield a large and diverse sample of 550 24-month-olds. Our key predictors will be toddler emergent language patterns (24-36 months), their neural biomarkers and synchrony within the transactional language environment. Our central outcome is primary language impairment (PLI) status at preschool age (54 mos., when PLI can be reliably evaluated), assessed via clinical gold standard expressive and receptive language abilities. SPECIFIC AIMS: AIM 1a. Evaluate accuracy of PLI prediction based on multi-component measures of language including intensive longitudinal assessments of toddler developmental precursors of key language functions at older ages, neural biomarkers. We will assess neural and linguistic processing via quantitative EEG during parent-child interaction and ERPs to speech sounds as well as during eye tracking tasks and 1b. Evaluate feasibility of creating an algorithm for early identification of PLI that can be applied in clinical practice, using cross-validation and machine learning. AIM 2: Test the hypothesis that parent-child dyadic synchrony buffers PLI risk For the first time, we combine behavioral and novel social EEG measures of parent-child synchrony during natural interaction and a custom-designed word learning task to directly test how observed (behavioral) and neural (EEG) dyadic synchrony impact word learning. AIM 3: Test whether consideration of toddler irritability enhances PLI prediction. In sum, PLI confers sustained negative effects on a variety of personal-social and academic outcomes. Pinpointing children at highest risk for PLI is critical for reducing the public health burden of PLI for children, families, and the systems supporting them, and enhancing targeted allocation of resources.

项目摘要 - 原始提交原发性语言障碍 (PLI) 始于生命早期，影响 6-8% 的儿童。干预越早提供，效果就越好，语言习得的规范性差异学步期（此处为 24-36 个月）阻碍了学龄前后期之前 PLI 的准确识别。拟议的研究介绍了一种新颖的、有理论依据的神经发育框架生成一个敏感且具体的模型来尽早识别 PLI 我们的发展- 敏感的转化方法引入了多项创新，包括：（1）表征使用最先进的方法从 24 个月开始幼儿新兴语言的发展模式， (2) 将语言的EEG/ERP神经生物标志物纳入PLI风险评估；（3）使用新颖的范式来评估行为和神经的保护作用亲子语言事务中的同步；以及（4）考虑易怒性，一个稳健的早期心理健康风险的发育标记，以加强对语言迟缓幼儿的识别对于建议的何时担心语言学习（W2W-L），我们面临最高的坚持风险。利用我们资助的 350 名婴儿（50% 易怒和 50% 非易怒）研究（R01MH107652，Wakschlag， PI）并通过招募 200 名晚说话的幼儿子样本来丰富它，这将产生大量且多样化的样本。我们的关键预测因素是 550 名 24 个月大的孩子的样本，即幼儿的新兴语言模式（24-36 个月），他们的神经生物标记和交易语言环境中的同步性是我们的核心成果。学龄前儿童的主要语言障碍 (PLI) 状况（54 个月，此时 PLI 可以得到可靠评估），通过临床金标准表达和接受语言能力进行评估。具体目标：AIM 1a。基于语言的多成分测量（包括强化）评估 PLI 预测的准确性对幼儿关键语言功能的发育前体进行纵向评估，神经我们将在亲子互动期间通过定量脑电图评估神经和语言处理。和 ERP 到语音以及眼动追踪任务和 1b 评估创建的可行性。使用交叉验证和可应用于临床实践的早期识别 PLI 的算法目标 2：测试亲子二元同步缓冲 PLI 风险的假设。当时，我们将自然行为期间亲子同步的行为和新颖的社会脑电图测量结合起来交互和定制设计的单词学习任务，以直接测试观察（行为）和神经的方式（脑电图）二元同步影响单词学习目标 3：测试是否考虑幼儿烦躁。增强 PLI 预测总而言之，PLI 对各种个人社会影响产生持续的负面影响。查明 PLI 风险最高的儿童对于减轻公共卫生负担至关重要。为儿童、家庭和支持他们的系统提供 PLI，并加强有针对性的资源配置。