Administrative Supplement to The When to Worry about Language Study (W2W-L)

何时担心语言学习 (W2W-L) 的行政补充

• 批准号: 10162280
• 负责人: Elizabeth Spencer Norton
• 金额: $ 19.71万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-05 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162280
• 关键词: Address; Administrative Supplement; Adverse effects; Affect; African American; Age; Algorithms; Behavioral; Biological Markers; Buffers; COVID-19; COVID-19 pandemic; Caregivers; Child; Child Language; Child Rearing; Clinical; Communities; Custom; Data; Data Collection; Development; Early Intervention; Early identification; Electroencephalography; Environment; Family; Family member; Foundations; Funding; Goals; Gold; Hispanics; Home environment; Human Subject Research; Illinois; Impairment; Individual; Infant; Institutes; Interruption; Intervention; Language; Language Delays; Language Development; Language Disorders; Life; Linguistics; Machine Learning; Measures; Mediating; Mental Health; Methods; Modeling; Nursery Schools; Outcome; Parent-Child Relations; Parents; Participant; Pattern; Pediatric Hospitals; Personal Satisfaction; Persons; Process; Protocols documentation; Public Health; Race; Research Activity; Resource Allocation; Risk; Risk Assessment; Sampling; Siblings; Speech Sound; Stress; Sum; Support System; Surveys; Testing; Time; Toddler; Transact; Translations; United States National Institutes of Health; Validation; Variant; Visit; base; clinical practice; cohort; coronavirus disease; design; experience; high risk; innovation; language impairment; negative affect; novel; pandemic disease; predictive modeling; prevent; protective effect; recruit; relating to nervous system; sex; social; standard measure; stress reduction; translational approach; tv watching; visual tracking; word learning

PROJECT SUMMARY – Original Submission Primary language impairment (PLI) begins early in life and affects 6-8% of children. Although language intervention is maximally effective the earlier it is delivered, normative variation in language acquisition across toddlerhood (here 24-36 months) impedes accurate identification of PLI prior to late preschool age. The proposed study introduces a novel, theoretically- grounded, neurodevelopmental framework designed to generate a sensitive and specific model to identify PLI as early as possible. Our developmentally- sensitive, translational approach introduces multiple innovations including: (1) characterizing the developmental patterning of toddler emergent language beginning at 24 mos. using state-of-the-art methods, within a large community sample; (2) incorporating EEG/ERP neural biomarkers of language into PLI risk assessment; (3) using a novel paradigm to assess the protective effects of both behavioral and neural synchronization within parent-child language transactions; and (4) consideration of irritability, a robust developmental marker of early mental health risk, to enhance identification of those language delayed toddlers at highest risk for persistence. For the proposed When to Worry about Language Study (W2W-L), we capitalize on our funded study of 350 infants (50% irritable and 50% non-irritable) (R01MH107652, Wakschlag, PI) and enrich it via recruitment of a sub-sample of 200 late talking toddlers. This will yield a large and diverse sample of 550 24-month-olds. Our key predictors will be toddler emergent language patterns (24-36 months), their neural biomarkers and synchrony within the transactional language environment. Our central outcome is primary language impairment (PLI) status at preschool age (54 mos., when PLI can be reliably evaluated), assessed via clinical gold standard expressive and receptive language abilities. SPECIFIC AIMS: AIM 1a. Evaluate accuracy of PLI prediction based on multi-component measures of language including intensive longitudinal assessments of toddler developmental precursors of key language functions at older ages, neural biomarkers. We will assess neural and linguistic processing via quantitative EEG during parent-child interaction and ERPs to speech sounds as well as during eye tracking tasks and 1b. Evaluate feasibility of creating an algorithm for early identification of PLI that can be applied in clinical practice, using cross-validation and machine learning. AIM 2: Test the hypothesis that parent-child dyadic synchrony buffers PLI risk For the first time, we combine behavioral and novel social EEG measures of parent-child synchrony during natural interaction and a custom-designed word learning task to directly test how observed (behavioral) and neural (EEG) dyadic synchrony impact word learning. AIM 3: Test whether consideration of toddler irritability enhances PLI prediction. In sum, PLI confers sustained negative effects on a variety of personal-social and academic outcomes. Pinpointing children at highest risk for PLI is critical for reducing the public health burden of PLI for children, families, and the systems supporting them, and enhancing targeted allocation of resources.

项目摘要 - 原始提交 初级语言障碍（PLI）在生命的早期开始，影响了6-8％的儿童。虽然语言 干预措施越早交付，是有效的，语言习得的正常差异 幼儿园（这里24-36个月）阻碍了幼儿园晚期之前对PLI的准确鉴定。 拟议的研究介绍了设计的小说，理论基础的神经发育框架 生成一个敏感和特定的模型以尽早识别PLI。我们的发展 - 敏感，翻译的方法引入了多种创新，包括：（1）表征 从24 mos开始开发幼儿新兴语言的模式。使用最先进的方法， 在大型社区样本中； （2）将语言的EEG/ERP神经生物标志物纳入PLI风险 评估; （3）使用新型范式评估行为和神经元的受保护作用 亲子语言交易中的同步； （4）考虑烦躁，强大的 早期心理健康风险的发展标志，以增强对这些语言延迟幼儿的识别 持久的风险最高。对于何时担心语言研究（W2W-L）的提议，我们 利用我们对350名婴儿的资助研究（50％易怒和50％的无呼能）（R01MH107652，Wakschlag， PI）并通过招募200个较晚的幼儿的子样本来丰富它。这将产生大型潜水员 550个24个月大的样本。我们的主要预测因素将是幼儿新兴语言模式（24-36个月）， 他们在交易语言环境中的神经生物标志物和同步。我们的主要结果是 学龄前年龄（54个月，PLI可以可靠评估时）的初级语言障碍（PLI）状态， 通过临床黄金标准表达和接受语言能力进行评估。具体目的：目标1A。 基于多组分的语言度量评估PLI预测的准确性，包括密集 幼儿对关键语言功能的发展前体的纵向评估，神经 生物标志物。我们将在亲子互动期间通过定量脑电图评估神经和语言处理 ERP和语音的声音以及眼睛跟踪任务和1B期间。评估创建一个可行性 用于早期鉴定PLI的算法，可用于临床实践，使用交叉验证和 机器学习。目标2：检验以下假设：第一个亲子二元同步缓冲pli pli first pli风险 时间，我们结合了自然过程中亲子同步的行为和新颖的社交脑电图测量 互动和定制设计的单词学习任务，以直接测试观察（行为）和神经 （EEG）二元同步影响单词学习。目标3：测试是否考虑幼儿烦躁 增强PLI预测。总而言之，PLI承认对各种个人社会和 学术成果。确定PLI风险最高的儿童对于减少Burnen的公共卫生至关重要 儿童，家庭和支持他们的系统的PLI，并增强有针对性的资源分配。