Emergency COVID-19 supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technoloites (ACME POCT)

亚特兰大微系统工程护理点技术中心 (ACME POCT) 的紧急 COVID-19 补充

基本信息

批准号：
10158197
负责人：
Oliver Brand
金额：
$ 3108.07万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-22 至 2021-05-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10158197
关键词：
Address Adoption Ambulances American Bedside Testings Biomedical Engineering Blood COVID-19 Cardiac Cardiology Care Technology Points Cellular Phone Child health care Clinical Clinical Research Clinical and Translational Science Awards Collaborations Country Critical Care Critical Illness Development Device or Instrument Development Devices Diagnosis Diagnostic Diagnostic tests Doctor of Philosophy Electronics Emergency Situation Engineering Equilibrium Fostering Funding Goals Guidelines Head Heart Heart Diseases Hematologist Hematology Home environment Hospitals Institutes International Leadership Lung Lung diseases Medical Device Medical Technology Microfluidics Monitor Movement Nanotechnology National Heart, Lung, and Blood Institute Organ Pathologic Pediatric Hospitals Physicians&apos Offices Play Population Pulmonology Recording of previous events Role Running Schools Side Signal Transduction Sleep System Technology Time Translations United States National Institutes of Health University Hospitals Validation Work base commercialization health care delivery innovation microchip microsystems novel point of care point-of-care diagnostics portability programs prototype public health relevance research clinical testing sensor sound

项目摘要

The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, and hematology, POC testing plays an especially significant role as the heart and lungs are among the most vital of organs necessitating real time diagnosis and rapid management during critical illnesses, while pathologic alternations in blood are associated with critical, systemic illness. One class of novel medical technologies that is showing promise for POC applications are microsystems-engineered technologies, that is, microchip-enabled devices ranging from microelectromechanical systems (MEMs)-based sensors, microfluidics, to even smartphone-based systems. Notable for their small size and power requirements, microchip-based systems provide the portability that is vital for POC testing. In addition, the capability of microsystems to convert sound and movement into electrical signals enable these technologies to be ideal devices to sense the dynamics of the lungs and heart and therefore to diagnose and monitor pulmonary and cardiac disorders. Moreover, microsystems engineering has brought forth the field of microfluidics, which is steadily finding applications for blood-based diagnostics, and therefore, hematologic applications. To that end, per the NHLBI's U54 POCTRN guidelines, the overall goal of the Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies for cardiac, pulmonary, hematologic and sleep applications that are beyond proof-of-concept to define their specific clinical needs, conduct clinical validation, and refine their technology, with the objective of accelerating the path to translation and clinical adoption and directly addressing the barriers thereof. The ACME POCT uniquely leverages Atlanta's nationally top-ranked clinical programs at Emory University's hospitals and Children's Healthcare of Atlanta, one of the nation's largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology (IEN), and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. The ACME POCT PI's uniquely balance the engineering and clinical sides of the Center and comprise Wilbur Lam, MD, PhD, a clinical hematologist at Emory and Georgia Tech bioengineer with expertise in POC diagnostic development and commercialization, Oliver Brand, PhD, a renowned microsystems engineer and head of Georgia Tech's IEN, and Greg Martin, MD, MSc, a clinical pulmonologist at Emory and head of clinical research in Atlanta's NIH-funded CTSA. Importantly, the leadership of the ACME POCT has a history of collaboration and track record in managing Centers that have fostered medical device development.

即时护理 (POC) 诊断功能的出现使得能够在医生办公室、救护车、家庭、现场或医院中进行快速、及时的临床评估，并有可能对医疗保健服务产生重大影响。在心脏病学、肺病学/重症监护和血液学中，POC 检测发挥着特别重要的作用，因为心脏和肺是最重要的器官之一，需要在危重疾病期间进行实时诊断和快速管理，而血液中的病理变化与危重症相关。、全身性疾病。一类在 POC 应用中显示出前景的新型医疗技术是微系统工程技术，即微芯片设备，范围从基于微机电系统 (MEM) 的传感器、微流体，甚至基于智能手机的系统。基于微芯片的系统以其小尺寸和功耗要求而著称，提供了对于 POC 测试至关重要的便携性。此外，微系统将声音和运动转换为电信号的能力使这些技术成为感知肺部和心脏动态的理想设备，从而诊断和监测肺部和心脏疾病。此外，微系统工程催生了微流体领域，该领域正在稳步寻找基于血液的诊断的应用，从而找到血液学的应用。为此，根据 NHLBI 的 U54 POCTRN 指南，亚特兰大微系统工程 POC 技术中心 (ACME POCT) 的总体目标是帮助和支持来自全国各地的发明家，他们开发了基于微系统的 POC 技术，用于心脏、肺、血液学和睡眠应用超出了概念验证范围，可定义其特定的临床需求、进行临床验证并完善其技术，其目标是加速转化和临床采用并直接解决障碍其中。 ACME POCT 独特地利用了亚特兰大埃默里大学医院和亚特兰大儿童保健中心（美国最大的儿科医院系统之一）的全国顶级临床项目，以及佐治亚理工学院国际知名的微系统工程专业知识，其中包括电子和技术研究所纳米技术 (IEN) 和其他独一无二的医疗设备原型设计、创新和测试平台设施。 ACME POCT PI 独特地平衡了该中心的工程和临床方面，成员包括埃默里大学临床血液学家 Wilbur Lam 和佐治亚理工学院的生物工程师，在 POC 诊断开发和商业化方面具有专业知识；Oliver Brand 博士是著名的微系统工程师乔治亚理工学院 IEN 负责人，格雷格·马丁 (Greg Martin)，医学博士、理学硕士，埃默里大学临床肺病学家，也是亚特兰大 NIH 资助的 CTSA 临床研究负责人。重要的是，ACME POCT 的领导层在管理促进医疗设备开发的中心方面拥有合作历史和良好记录。