Direct quantification of toxic substances in frozen tissues by MALDI-MS/MS

通过 MALDI-MS/MS 直接定量冷冻组织中的有毒物质

• 批准号: 16K09206
• 负责人: Minakata Kayoko
• 金额: $ 3万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09206/
• 关键词: 質量分析; 薬毒物; 危険ドラッグ; 合成カンナビノイド; 代謝物; 高感度分析; 尿; 高感度定量; ジフェニジン; 凍結切片; mass spectrometry; MALDI; 脂肪組織; 標準添加法; 社会医学; 分析科学; 薬学; 有機化学

项目成果

Fatal zolpidem poisoning due to its intravenous self-injection: Post mortem distribution/redistribution of zolpidem and its predominant metabolite zolpidem phenyl-4-carboxylic acid in body fluids and solid tissues in an autopsy case

静脉自我注射导致致命的唑吡坦中毒：尸检病例中唑吡坦及其主要代谢物唑吡坦苯基-4-羧酸在体液和实体组织中的死后分布/再分布

• DOI: 10.1016/j.forsciint.2018.06.044
• 发表时间: 2018
• 影响因子: 2.2
• 作者: Koutaro Hasegawa; Amin Wurita; Hideki Nozawa; Itaru Yamagishi; Kayoko Minakata; Kanako Watanabe; Osamu Suzuki
• 通讯作者: Osamu Suzuki

Postmortem redistribution of methamphetamine and amphetamine in blood specimens from various blood vessels and in the specimens from rericardial fluid, bile, stomach contents and various solid tissues collected from a human cadaver

死后甲基苯丙胺和苯丙胺在各种血管的血液样本以及从人体尸体收集的心室液、胆汁、胃内容物和各种固体组织的样本中的重新分布

• DOI: 10.1007/s11419-015-0303-8
• 发表时间: 2016
• 影响因子: 2.2
• 作者: Amin W; Hasegawa K; Minakata K; Gonmori K; Nozawa H; Yamagishi I; Suzuki O; Watanabe K
• 通讯作者: Watanabe K

Sensitive quantification of 5F-PB-22 and its three metabolites 5F-PB-22 3-carboxyindole, PB-22 N-5-hydroxypentyl and PB-22 N-pentanoic acid in authentic urine specimens obtained from four individuals by liquid chromatography-tandem mass spectrometry

通过液相色谱串联法对四个个体的真实尿液样本中的 5F-PB-22 及其三种代谢物 5F-PB-22 3-羧基吲哚、PB-22 N-5-羟基戊基和 PB-22 N-戊酸进行灵敏定量

• DOI: 10.1007/s11419-017-0395-4
• 发表时间: 2018
• 影响因子: 2.2
• 作者: Kayoko Minakata; Koutaro Hasegawa; Itaru Yamagishi; Hideki Nozawa; Hanajiri RK; Masako Suzuki; Takuya Kitamoto; Osamu Suzuki; Kanako Watanabe
• 通讯作者: Kanako Watanabe

Simultaneous determination of cyclic antidepressants and their related drugs and the estimation of new metabolites in human whole blood and urine by MALDI-QTOF-mass spectrometry

MALDI-QTOF-质谱法同时测定环状抗抑郁药及其相关药物并估算人全血和尿液中的新代谢物

• DOI: 10.1007/s11419-016-0313-1
• 发表时间: 2016
• 影响因子: 2.2
• 作者: Nozawa H; Minakata K; Yamagishi I; Hasegawa K; Suzuki M; Gonmori K; Suzuki O; Watanabe K
• 通讯作者: Watanabe K

A case of intoxication with a mixture of synthetic cannabinoids EAM-2201, AB-PINACA and AB-FUBINACA, and a synthetic cathinone α-PVP

合成大麻素 EAM-2201、AB-PINACA 和 AB-FUBINACA 以及合成卡西酮 α-PVP 混合物中毒事件

• 发表时间: 2018
• 作者: Itaru Yamagishi; Kayoko Minakata; Hideki Nozawa; Koutaro Hasegawa; Masako Suzuki; Takuya Kitamoto; Osamu Suzuki; Kanako Watanabe
• 通讯作者: Kanako Watanabe