CARE AND HOUSING OF AIDS RESEARCH ANIMALS

艾滋病研究动物的护理和饲养

• 批准号: 3594551
• 负责人: JERE M PHILLIPS
• 金额: $ 8.5万
• 依托单位: SEMA, INC.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3594551
• 关键词: AIDS; Aotus; Macaca mulatta; Pan; Rotavirus; Saimiri; animal colony; human therapy evaluation; respiratory infections; viral vaccines

Maintain nonhuman primates in biohazard containment facilities for studies of AIDS and selected human respiratory tract and enteric diseases. In addition, many technical procedures will be performed on the animals. Testing of various reassortant influenza viruses, human respiratory syncytial viruses, and rotaviruses will be done in squirrel monkeys, owl monkeys, chimpanzees, and rhesus monkeys. As an animal model of human AIDS, up to nine chimpanzees will be inoculated with selected human material, then monitored for clinical or hematological signs of disease. This investigation will be long-term, continuing for at least two years post inoculation. Studies with respiratory tract infections will primarily be focused on testing of candidate vaccine strains and will involve from four to twenty-two animals per study. Individual studies will likely not exceed two months in duration, and up to fourteen studies will beperformed each year.

在生物危害遏制设施中饲养非人类灵长类动物进行研究 艾滋病和某些人类呼吸道和肠道疾病。 在 此外，还将对动物进行许多技术程序。 检测各种重配流感病毒、人类呼吸道病毒 合胞病毒和轮状病毒将在松鼠猴、猫头鹰中进行 猴子、黑猩猩和恒河猴。 作为人类艾滋病的动物模型， 多达九只黑猩猩将接种选定的人类材料， 然后监测疾病的临床或血液学迹象。 这 调查将是长期的，至少持续两年 接种。 呼吸道感染的研究主要是 重点是候选疫苗株的测试，将涉及四个 每项研究二十二只动物。 个别研究可能不会超过 为期两个月，每次将进行多达十四项研究 年。