Exploration of Novel Markers on Cancer and Development of a Technology for the Diagnosis Utilized by Comprehensive Glycomics

新型癌症标志物的探索及综合糖组学诊断技术的开发

• 批准号: 25220206
• 负责人: Nishimura Shin-Ichiro
• 金额: $ 126.8万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-05-31 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25220206/
• 关键词: 癌バイオマーカー; 癌早期発見; 糖鎖解析; 大規模糖鎖構造解析; 糖鎖工学; 疾患糖鎖データベース; 抗体医薬; 動的エピトープ; 糖鎖; グライコブロッティング法; グライコミクス; 疾患マーカー; 肝細胞癌; 膵癌; 腎細胞癌; 早期診断法; 診断薬探索; ケミカルバイオロジー; 生体分子; バイオマーカー

项目成果

Preoperative chronic kidney disease predicts poor oncological outcomes after radical cystectomy in patients with muscle-invasive bladder cancer.

• DOI: 10.18632/oncotarget.18248
• 发表时间: 2017-09-22
• 期刊: Oncotarget
• 作者: Hamano I;Hatakeyama S;Iwamurau H;Fujita N;Fukushi K;Narita T;Hagiwara K;Kusaka A;Hosogoe S;Yamamoto H;Tobisawa Y;Yoneyama T;Yoneyama T;Hashimoto Y;Koie T;Ito H;Yoshikawa K;Kawaguchi T;Ohyama C
• 通讯作者: Ohyama C

Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats

多重O-糖基化状态对MUC1胞外串联重复序列中免疫显性基序的抗体识别的影响

• DOI: 10.1039/c6md00100a
• 发表时间: 2016
• 期刊: MedChemComm
• 作者: Rangappa S.;Artigas G.;Miyoshi R.;Yokoi Y.;Hayakawa S.;Fayna Garcia-Martin;Hinou H.;Nishimura S-I.
• 通讯作者: Nishimura S-I.

An Automated Micro-Total Immunoassay System for Measuring Cancer-Associated α2,3-linked Sialyl N-Glycan-Carrying Prostate-Specific Antigen May Improve the Accuracy of Prostate Cancer Diagnosis.

• DOI: 10.3390/ijms18020470
• 发表时间: 2017-02-22
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Ishikawa T;Yoneyama T;Tobisawa Y;Hatakeyama S;Kurosawa T;Nakamura K;Narita S;Mitsuzuka K;Duivenvoorden W;Pinthus JH;Hashimoto Y;Koie T;Habuchi T;Arai Y;Ohyama C
• 通讯作者: Ohyama C

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.

• DOI: 10.3390/ijms18020261
• 发表时间: 2017-01-26
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Hagiwara K;Tobisawa Y;Kaya T;Kaneko T;Hatakeyama S;Mori K;Hashimoto Y;Koie T;Suda Y;Ohyama C;Yoneyama T
• 通讯作者: Yoneyama T

Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs

• DOI: 10.1021/acs.jmedchem.7b01242
• 发表时间: 2017-11-09
• 期刊: JOURNAL OF MEDICINAL CHEMISTRY
• 影响因子: 7.3
• 作者: Artigas, Gerard;Monteiro, Joao T.;Garcia-Martin, Fayna
• 通讯作者: Garcia-Martin, Fayna