PPAR-alpha mediated molecular mechanisms involved in spontaneous hepatocarcinogenesis among NASH mouse model

PPAR-α介导的NASH小鼠模型自发性肝癌发生的分子机制

• 批准号: 15K09010
• 负责人: SAIBARA Toshiji
• 金额: $ 3万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09010/
• 关键词: PPAR-alpha; melanocortin receptor; insulin resistance; fatty liver; IL-6; NASH; hepatocellular carcinoma; knockout mouse; Melanocortin receptor; 肝硬変; 肝細胞癌; ＭＣ４Ｒ; ノックアウトマウス

项目成果

Characterization of ovarian responses to equine chorionic gonadotropin of aromatase-deficient mice with or without 17-estradiol supplementation.

具有或不具有 17 的芳香酶缺陷小鼠的卵巢对马绒毛膜促性腺激素的反应特征

• DOI: 10.1210/en.2015-1701
• 发表时间: 2016
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Katsumi Toda;Yoshihiro Hayashi;Masafumi Ono;Toshiji Saibara
• 通讯作者: Toshiji Saibara

Are genetic variations the most important risk factors for development of hepatocellular carcinoma?

• DOI: 10.1007/s00535-015-1130-8
• 发表时间: 2016-04
• 期刊: Journal of Gastroenterology
• 影响因子: 6.3
• 作者: M. Ono;T. Saibara

Involvement of PNPLA3 function for hepatic lipids metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice

PNPLA3 通过 XBP1 参与肝脂质代谢功能并调节小鼠内质网应激

• 发表时间: 2017
• 作者: Seko Yuya;Sumida Yoshio;Tanaka Saiyu;Mori Kojiroh;Taketani Hiroyoshi;Ishiba Hiroshi;Hara Tasuku;Okajima Akira;Umemura Atsushi;Nishikawa Taichiro;Yamaguchi Kanji;Moriguchi Michihisa;Kanemasa Kazuyuki;Yasui Kohichiroh;Imai Shunsuke;Shimada Keiji;Itoh Yoshit;Nagano S，Ono M，Ochi T，Munekage K，Yano Y，Mizuta H，Ogasawara M，Hirose A，Nozalki Y，Okamoto N，Iwasaki S，Jude A ObenT，Saibara T
• 通讯作者: Nagano S，Ono M，Ochi T，Munekage K，Yano Y，Mizuta H，Ogasawara M，Hirose A，Nozalki Y，Okamoto N，Iwasaki S，Jude A ObenT，Saibara T

PNPLA3 IS INVOLVED IN HEPATIC LIPIDS METABOLISM THROUGH XBP1 AND MODUALATION OF ENDOPLASMIC RETICULUM SYRESS IN MICE

PNPLA3 通过 XBP1 参与肝脏脂质代谢以及小鼠内质网系统的调节

• 发表时间: 2016
• 作者: Ikeda M;Shimizu S;Sato T;Morimoto M;Kojima Y;Inaba Y;Hagihara A;Kudo M;Nakamori;Kaneko S;Sugimoto R;Tahara T;Ohmura T;Yasui K;Sato K;Ishii H;Furuse J;Okusaka T.;Yano Y，Mizuta H， Ono M，Saibara T.(他6名);Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T
• 通讯作者: Ono M，Ochi T，Munegage K，Ogasawara M，Hirose A，Nozaki-Fujimura Y，Okamoto N， Iwasaki S，Oben J，Saibara T

Prevalence of pruritus in patients with chronic liver disease: A multicenter study

• DOI: 10.1111/hepr.12978
• 发表时间: 2018-02-01
• 期刊: HEPATOLOGY RESEARCH
• 影响因子: 4.2
• 作者: Oeda, Satoshi;Takahashi, Hirokazu;Eguchi, Yuichiro
• 通讯作者: Eguchi, Yuichiro