Mechanisms of life-shrecthening attacks of asthma.

哮喘致命发作的机制。

基本信息

批准号：
09670592
负责人：
KIKUCHI Yoshihiro
金额：
$ 1.73万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670592/
关键词：
Bronchial asthma Death from asthma Dyspnea hypoxia beta2-stimulant inhalation β刺激剤吸入

项目摘要

The purpose of the present was to examine the precise mechanisms of death from asthma attacks. Specifically, I intended to clarify my hypothesis that an increase in physical activity and/or an inhalation of beta2-stimulant during an exerbation of asthma maybe a trigger of unconsciousness, leading to death.Main findings in this project were as follows.1. I interviewed to 28 patients with near-fatal asthma, who had in experience of unconsciousness during an attack or had received treatment with a mechanical ventilator. Sixty-eight percent of their near-fatal episodes had occurred just after the increasing physical activity, in particular walking, and 17 percent had occurred after/or during the inhalation of beta2-stimulant through an ultrasonic nebulizer. These results suggest that the increase in physical activity and the inhalation of beta2-stimulant during an exerbation of asthma may be a trigger of unconsciousness, leading to death.2 It was also demonstrated that both the increase physical activity and the inhalation of beta2-stimulant decreased in arterial oxygen saturation during an exacerbation of asthma. The more severe airway bronchoconstriction expressed by peak expiatory flow was, the more oxygen saturation decreased by an inhalation of beta2-stimulant.3. It was demonstrated that doxapram increases the perception of dyspnea during breathing through resistances as well as hypoxic ventilatory response. This suggest that doxapram may improve the two risk factors, i.e. blunted perception of dyspnea and lower edhypoxic ventilatory response, of patients with near-fatal asthma. This drug may be useful for a treatment for patients with near-fatal asthma.

目前的目的是检查哮喘发作中死亡的确切机制。具体而言，我旨在澄清我的假设，即在哮喘的消除过程中，体育活动和/或吸入beta2刺激剂的增加可能是一种无意识的触发因素，导致死亡。该项目中的梅恩发现如下。1。我采访了28例近乎致命哮喘的患者，他们在攻击过程中具有无意识经验，或者接受过机械呼吸机的治疗。他们的近乎致命的发作中有68％发生在体育锻炼的增加之后，尤其是步行，而在通过超声雾化器吸入beta2刺激剂后发生了17％。 These results suggest that the increase in physical activity and the inhalation of beta2-stimulant during an exerbation of asthma may be a trigger of unconsciousness, leading to death.2 It was also demonstrated that both the increase physical activity and the inhalation of beta2-stimulant decreased in arterial oxygen saturation during an exacerbation of asthma.通过峰值流量表达的较严重的气道支气管收缩是，通过吸入beta2刺激剂的氧饱和度越多。3。已经证明，多克萨普拉姆通过电阻和低氧通气反应在呼吸过程中增加了呼吸困难的感知。这表明Doxapram可能会改善两个危险因素，即对呼吸困难的呼吸困难和降低的edhypoxic通气反应，对近乎致命的哮喘患者进行较低的危险因素。该药物可能可用于近乎致命哮喘患者的治疗。