Dissipative Supramolecular Reactor

耗散超分子反应器

• 批准号: 22KF0395
• 负责人: 相田 卓三
• 金额: $ 1.34万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2023
• 资助国家: 日本
• 起止时间: 2023-03-08 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0395/
• 关键词: Perfluorinated Crown; Supramolecular Adhesive; Water Cluster; Membrane Transporter; Supramolecular polymer; Perfluorinated monomer

Our novel synthetic strategy for functionalizing perfluoro crown ethers has potential applications in various fields. Strategically designed crown ether derivatives form strong supramolecular polymers in the molten state with high adhesive strength and toughness, attributed to dynamic hydrogen bonding and Fluorine-Fluorine interactions. This material shows excellent underwater and PTFE sheet adhesion, making it a potential replacement for conventional adhesive polymers. Additionally, crown ether derivatives exhibit strong interactions with water clusters, allowing them to penetrate cell membranes quickly. Whereas the corresponding nonfluorinated analog failed to penetrate the membrane bilayer even after prolonged incubation, making them suitable for medicinal chemistry and drug delivery.

我们新颖的全氟冠醚功能化合成策略在各个领域都有潜在的应用。精心设计的冠醚衍生物在熔融状态下形成坚固的超分子聚合物，由于动态氢键和氟-氟相互作用，具有高粘合强度和韧性。这种材料在水下和 PTFE 片材上表现出优异的粘合力，使其成为传统粘合剂聚合物的潜在替代品。此外，冠醚衍生物与水簇表现出强烈的相互作用，使它们能够快速穿透细胞膜。而相应的非氟化类似物即使在长时间孵育后也无法穿透双层膜，这使得它们适用于药物化学和药物输送。