Analysis of the relationship between antidepressant-induced Syndrome maline and Pharmaco Kinetic

抗抑郁药诱发的男性综合征与药代动力学关系分析

• 批准号: 09672320
• 负责人: OHTANI Hisakazu
• 金额: $ 1.34万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672320/
• 关键词: Syndrome maline; antidepressant; Clomipramine; Veratrine; fever; 5-HT; microdialysis; rats; 発熱反応

Syndrome maline with clinical futures such as fever, myoclonus, hidropoiesis and mental status changes is recognized as a severe adverse reaction. Recently, the syndrome maline induced by antidepressant has been also reported in human beings.The purpose of the present study is to prepare the syndrome maline model rats, to induce fever which is one of pathognomonic symptom of the syndrome maline after administration of several serotonin (5-HT) reuptake inhibitors to the model rats, to elucidate the relationship between pharmacokinetics of antidepressant and 5-HT levels in brain, or elevated fever. Final goal is In addition.In 1997, Firstly, we developed a high performance liquid chromatographic method for determination of antidepressant, clomipramine, in biological samples. Clomipramine concentrations in plasma and brain after intravenous administration of the drug to intact rats were measured by the analytical method, and the pharmacokinetics of clomipramine was analyzed. Then, clomipramine was administered intraperitoneally to rats after veratrine, a neurotransmitter releasing agent, was injected to the PO/AH.By the administration method, we could reproduced the elevated fever as a marker of the syndrome maline. In 1998, we measured 5-HT level in fat brain after coadministration of veratrine and clomipramine. The 5-HT level in brain with veratrine we higher than that without.

具有临床期货的综合征症状，例如发烧，Myoclonus，Hidropoiesis和心理状况变化，被认为是严重的不良反应。最近，还报道了人类中抗抑郁药诱导的症状症状。本研究的目的是准备综合征麦磷脂模型大鼠，诱导发烧，这是给药后症状症的病理学症状之一（给药后，麦芽综合征症状症状之一（ 5-HT）对模型大鼠的再摄取抑制剂，以阐明抗抑郁药的药代动力学与大脑中5-HT水平或发烧升高之间的关系。最终目标是加上。在1997年，首先，我们开发了一种高性能液相色谱方法，用于测定生物样品中的抗抑郁药，氯米帕明。通过分析方法测量了药物静脉内给药后血浆和大脑中的氯米帕明浓度，并分析了氯米帕明的药代动力学。然后，在神经递质（一种神经递质释放剂）后，将氯米帕明腹膜内腹膜内腹膜内腹膜内，将其注射到PO/AH.通过给药方法中，我们可以将升高的发烧作为综合征症状的标记。在1998年，我们在肾上腺素和氯米帕明共同给药后测量了脂肪脑中的5-HT水平。黄体中的5-HT水平我们没有比没有的。