Elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition mediated by DeltaNp63

DeltaNp63介导的上皮间质转化导致口腔鳞癌发生、侵袭和转移的分子机制阐明

• 批准号: 24792231
• 负责人: MATSUBARA Ryota
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792231/
• 关键词: ΔNp63; 口腔扁平上皮癌; 上皮ー間葉転換（EMT）; 浸潤・転移; EMT; 癌幹細胞

The purpose in this study is elucidation on the molecular mechanisms of the carcinogenesis, invasion, and metastasis of oral squamous cell carcinoma due to epithelial-to-mesenchymal transition (EMT) mediated by DeltaNp63.As the results, It is suggested that DeltaNp63 downregulation induced EMT in oral squamous cell carcinoma. DeltaNp63 possibly involved in acquirement of the ability of the invasion, metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype.

本研究的目的是阐明DeltaNp63介导的上皮间质转化（EMT）导致口腔鳞状细胞癌发生、侵袭和转移的分子机制。口腔鳞状细胞癌的 EMT。 DeltaNp63可能通过诱导间充质表型参与口腔鳞癌侵袭、转移能力的获得。

项目成果

Carcinoma ex pleomorphic adenoma of the upper lip : A case of an unusual malignant component of squamous cell carcinoma

上唇多形性腺​​瘤癌：鳞状细胞癌罕见恶性成分一例

• 发表时间: 2013
• 影响因子: 3.2
• 作者: Eiji Mitate; Shintaro Kawano; Tamotsu Kiyoshima; Toru Chikui; Yuichi Goto; Ryota Matsubara; Seiji Nakamura
• 通讯作者: Seiji Nakamura

Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype

ΔNp63下调可能通过诱导间充质表型参与口腔鳞状细胞癌的侵袭和转移

• 发表时间: 2014
• 影响因子: 4
• 作者: Yuichi Goto; Shintaro Kawano; Ryota Matsubara; Takahiro Kiyosue; Mitsuhiro Hirano; Teppei Jinnno; Yasuyuki Maruse; Takeshi Toyoshima; Ryoji Kitamura Hideaki Tanaka; Kazunari Oobu; Seiji Nakamura
• 通讯作者: Seiji Nakamura

Parotid gland myoepithelioma with remarkable cystic formation : A case report

具有显着囊性形成的腮腺肌上皮瘤：一例报告

• 发表时间: 2013
• 作者: Hiroe Kakehashi; Shintaro Kawano; Tamotsu Kiyoshima; Mayumi Shimizu; Masafumi Moriyama; Ryota Matsubara; Takahiro Kiyosue; Yuichi Goto; Hideki Shiratsuchi; Seiji Nakamura
• 通讯作者: Seiji Nakamura

Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma

F-18 FDG PET最大标准化摄取值与淋巴结大小联合评估诊断口腔鳞癌颈淋巴结转移的临床意义

• 发表时间: 2012
• 影响因子: 4.8
• 作者: Ryota Matsubara; Shintaro Kawano; Toru Chikui; Takahiro Kiyosue; Yuichi Goto; Mitsuhiro Hirano; Teppei Jinno; Tetsuji Nagata; Kazunari Oobu; Koichiro Abe; Seiji Nakamura
• 通讯作者: Seiji Nakamura

Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma

肿瘤相关抗原RCAS1在口腔鳞癌中的凋亡功能

• 影响因子: 7.4
• 作者: Hideaki Tanaka; Takeshi Toyoshima; Kenzo Sonoda; Ryoji Kitamura; Masaaki Sasaguri; Shintaro Kawano; Ryota Matsubara; Yuichi Goto; Seiji Nakamura
• 通讯作者: Seiji Nakamura