Base study for the radical treatment of the cedar pollinosis by the identification of the Tr1 instruction cedar pollen epitope

Tr1指令柳杉花粉表位鉴定根治柳杉花粉病的基础研究

• 批准号: 24791780
• 负责人: NODA Yohei
• 金额: $ 2.75万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791780/
• 关键词: スギ花粉症; 健常人; IL-10; 制御性細胞; ペプチド; 免疫寛容; 制御性Ｔ細胞; LAG-3; 制御性T細胞

We sought to determine the cellular responses to Cry j 1, the major allergen of Japanese cedar pollen, in healthy Japanese. Peripheral blood mononuclear cells produced a substantial amount of IL-10 in response to Cry j 1. We synthesized 45 overlapping peptide with 15 amino acids from N-terminal of Cry j 1. However, we could not find a particular peptide in which PBMCs from healthy subjects produced IL-10. In addition, we found that LAG-1 and CD201 positive population in CD4 positive cells were increased in response to Cry j 1, suggesting that Tr1 is induced in healthy subject following the exposure to Japanese cedar pollen

我们试图确定健康日本人对日本雪松花粉的主要过敏原 Cry j 1 的细胞反应。外周血单核细胞响应 Cry j 1 产生大量的 IL-10。我们从 Cry j 1 的 N 端合成了 45 个具有 15 个氨基酸的重叠肽。然而，我们找不到其中来自 PBMC 的特定肽。健康受试者产生IL-10。此外，我们发现 CD4 阳性细胞中的 LAG-1 和 CD201 阳性数量因 Cry j 1 的反应而增加，表明健康受试者在接触日本柳杉花粉后诱导了 Tr1

项目成果

Early interventional treatment with intranasal corticosteroids is superior to post-onst treatment in pollinosis

花粉症早期鼻内皮质类固醇介入治疗优于术后治疗

• 发表时间: 2012
• 作者: Higaki T; Okano M; Makihara S; Fujiwara T; Haruna T; Noda Y; Kariya S; Nishizaki K
• 通讯作者: Nishizaki K

咽頭表在癌ESD後の頸部リンパ節転移の検討

浅表咽癌ESD术后颈部淋巴结转移的检查

• 发表时间: 2014
• 作者: 野田洋平

頭頸部癌に対する放射線科学療法後の甲状腺機能低下症の検討

头颈癌放射治疗后甲状腺功能减退症的检查

• 发表时间: 2013
• 作者: 野田洋平

Characterization of IL-18 expression and release in the pathogenesis of chronic rhinosinusitis

慢性鼻窦炎发病机制中IL-18表达和释放的特征

• 发表时间: 2013
• 影响因子: 2.8
• 作者: Okano M; Fujiwara T; Makihara S; Fujiwara R; Higaki T; Kariya S; Noda Y; Haruna T; Nishizaki K
• 通讯作者: Nishizaki K

COX/PGE2 axis critically regulates effects of LPS on eosinophilia-associated cytokine production innasal polyps

COX/PGE2 轴关键调节 LPS 对鼻息肉嗜酸性粒细胞相关细胞因子产生的影响

• 发表时间: 2012
• 作者: Higaki T; Okano M; Fujiwara T; Makihara S; Kariya S; Noda Y; Haruna T; Nishizaki K
• 通讯作者: Nishizaki K