Spatiotemporal dynamics within memory traces studied by induced gamma-band oscillations in the human EEG and coupling measures in source space

通过人类脑电图感应伽玛波段振荡和源空间耦合测量研究记忆痕迹内的时空动力学

• 批准号: 72251038
• 负责人: Professor Dr. Thomas Gruber
• 金额: --
• 依托单位: Fachgebiet Allgemeine Psychologie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/72251038?language=en
• 关键词: Spatiotemporal; dynamics; within; memory; traces

One of the more fundamental questions in memory research is how the brain integrates the distributed storage- and executive cortical areas necessary for the activation of a specific ‘memory trace’. It is hypothesized that this integration is achieved by synchronized oscillations in the gamma-band frequency range (>25Hz). In particular, induced gamma-band responses (iGBRs; ~150-400ms) might signify the activation of conceptual engrams, whereas evoked gamma-band responses (eGBRs; ~90ms) might mirror perceptual memory.The first goal of present project is to deepen the knowledge regarding the mechanism by which such memory traces are altered during implicit and explicit memory. To that end, we will rely on stimulus repetition designs. A second central aim is the examination of the spatiotemporal dynamics within specific memory traces by means of advanced analysis procedures: (a) Gamma-band source reconstructions and (b) functional and effective coupling measures in source space.Complementary correlates of memory (ERPs, lower-frequency oscillations) will be studied in their relation to gamma oscillations.

记忆研究中最根本的问题之一是大脑如何整合激活特定“记忆痕迹”所需的分布式存储和执行皮质区域。假设这种整合是通过在伽马频段频率范围（> 25Hz）中的同步振荡来实现的。特别是，诱导的γ波段响应（IGBR； 〜150-400ms）可能表示概念上的激活的激活，而唤起的γ波段响应（EGBRS; 〜90ms）可能会反映出感知记忆。本项目的第一个目标是在这种记忆迹象上的知识中，在这种内存迹象上会改变并置于内存的内存，并置入依据。为此，我们将依靠刺激重复设计。第二个中心目的是通过高级分析程序检查特定内存痕迹中的空间时间动力学：（a）伽马频段源重建和（b）源空间中的功能有效耦合度量。