Identification of neural circuits that control social behavior

识别控制社会行为的神经回路

• 批准号: 23700397
• 负责人: MIZUGUCHI Rumiko
• 金额: $ 2.83万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700397/
• 关键词: 軸索性細胞認識分子; BIG-2; オープンフィールドテスト; 不安行動; 視床下部; 室傍核; 細胞認識分子; 自閉症スペクトラム症候群; BIG-2 (contactin-4); 視床下部室傍核; ストレス応答; 神経回路形成; 軸索性細胞認識因子; 攻撃行動; 社会的行動

BIG-2 is an axon-associated cell recognition molecule that is involved in neural circuit formation in the brain. Recent studies implicated that BIG-2 is related to autism spectrum disorders (ASD). We previously found that BIG-2 knockout mice show increased anxiety in open field test and elevated plus maze test. To identify brain regions responsible for this abnormality, we mapped brain areas that were activated during the behavioral tests. We found that neuronal activity was elevated in parvocellular population of paraventricular hypothalamic nucleus (PVH) in BIG-2 knockout mice after subjected to open field test. As PVH is known to play central roles in stress response, it is suggested that BIG-2 is involved in formation of neural circuits required for proper stress responses in novel environment.

BIG-2 是一种轴突相关细胞识别分子，参与大脑神经回路的形成。最近的研究表明 BIG-2 与自闭症谱系障碍 (ASD) 有关。我们之前发现BIG-2基因敲除小鼠在旷场测试和高架十字迷宫测试中表现出焦虑增加。为了确定导致这种异常的大脑区域，我们绘制了行为测试期间激活的大脑区域。我们发现，在进行旷场测试后，BIG-2 敲除小鼠的室旁下丘脑核 (PVH) 的小细胞群中的神经元活性升高。由于 PVH 已知在应激反应中发挥核心作用，因此表明 BIG-2 参与新环境中适当应激反应所需的神经回路的形成。