The recovery mechanism and cell injury from orthodontic treatment with promoter of transplanted bone marrow-derived cell migration into periodontal tissues

促进移植骨髓来源细胞迁移至牙周组织的正畸治疗的恢复机制及细胞损伤

• 批准号: 23792456
• 负责人: MURAOKA Rina
• 金额: $ 2.66万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792456/
• 关键词: 骨髄幹細胞; 歯根膜; 歯周組織; 歯科矯正学; 治療; 修復; 再生; リモデリング; 細胞分化; 組織修復

In this study, we aimed that the elucidation of the molecular regulation mechanism of recovery and cytotoxicity of periodontal tissue by orthodontic mechanical stress, and to clarify the development of the control method, the full particulars of the function and dynamics of bone marrow-derived cell.Using the mouse that performed the bone marrow-derived cell transplantation, and were elucidated the involvement of bone marrow-derived cell in the surrounding bone and tissue study of cell injury to receive the periodontal ligament fibroblasts in particular periodontal ligament tissue loaded with orthodontic academic ability in mouse molars. Bone marrow stem cells were shown to engraft in a thriving site remodeling mostly in periodontal tissue showed experimentally that this phenomenon is associated with the dense and cells of the nervous system.

本研究旨在阐明正畸机械应力对牙周组织恢复和细胞毒性的分子调控机制，阐明控制方法的发展、骨髓源性细胞功能和动态的详细情况。 .利用进行骨髓源性细胞移植的小鼠，并阐明骨髓源性细胞参与周围骨组织细胞损伤的研究来接受牙周膜成纤维细胞，特别是牙周膜组织，在小鼠磨牙中具有正畸学术能力。骨髓干细胞被证明可以移植到牙周组织的繁荣部位进行重塑，实验表明这种现象与神经系统的致密和细胞有关。

项目成果

Immunohistochemical Expression of Osterix Appearing in the Mouse Orthodontic Periodontal Tension Sides

小鼠正畸牙周张力侧Osterix的免疫组织化学表达

• 发表时间: 2012
• 作者: Toshihisa Harada Rina Muraoka;他6名
• 通讯作者: 他6名

Immunohistochemical Changes of Heat Shock Protein 27 Expression in the Mouse Periodontal Tissues Exposed to Orthodontic Mechanical Stress

正畸机械应力小鼠牙周组织热休克蛋白27表达的免疫组化变化

• DOI: 10.2485/jhtb.21.43
• 发表时间: 2012
• 影响因子: 0.4
• 作者: Tomoda M; Nakano K; Muraoka R; Matsuda H; Yamada K;Kawakami T
• 通讯作者: Kawakami T

歯科矯正力によりマウス歯周組織に発現するOsterixの免疫組織化学的観察

正畸力作用下小鼠牙周组织中Osterix表达的免疫组化观察

• 发表时间: 2011
• 作者: 松田浩和;村岡理奈;他3名
• 通讯作者: 他3名

Immunihistochemical expression of HSP27 in the mouse periodontal tissues due to orthodontic mechanical stress

正畸机械应力所致小鼠牙周组织中HSP27的免疫组织化学表达

• 发表时间: 2011
• 作者: Muraoka R; et al.
• 通讯作者: et al.

実験的歯科矯正力により歯根膜組織に発現するHSP70の役割に関する一考察

牙周膜组织表达的HSP70对实验正畸力作用的研究

• 发表时间: 2011
• 作者: 村岡理奈;他6名
• 通讯作者: 他6名