Mechanism in retinal diseases by extra-cellular matrix and prevention to blindness

细胞外基质在视网膜疾病中的作用机制及防盲作用

• 批准号: 23592566
• 负责人: IKUNO Yasushi
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592566/
• 关键词: ペリオスチン; 加齢黄斑変性; 網膜; 眼科; 脈絡膜新生血管; 脈絡膜; 糖尿病網膜症; 緑内障

Choroidal neovascularization model was established in mouse model, and the mRNA expression of periostin that regulates the extra-cellular matrix was investigated using polymerase chain reaction. Soon after induction, the periostin expression was slowly up-regulated, and maintained for 28 days. While tumor necrosis factor-alpha, which was used for control, showed an acute increase. This data indicates that periostin is specifically introduced by choroidal neovascularization, and prevention of periostin expression can be an preventive treatment for such conditions as age-related macular degeneration.

建立小鼠脉络膜新生血管模型，采用聚合酶链式反应研究调节细胞外基质的periostin mRNA表达。诱导后不久，periostin表达缓慢上调，并维持28天。而用于对照的肿瘤坏死因子-α则显示出急剧增加。该数据表明骨膜素是由脉络膜新生血管特异性引入的，并且预防骨膜素表达可以作为年龄相关性黄斑变性等病症的预防性治疗。

项目成果

Comparison of enhanced depth imaging and high-penetration optical coherence tomography for imaging deep optic nerve head and parapapillary structures

增强深度成像与高穿透光学相干断层扫描对深部视神经乳头和视乳头旁结构成像的比较

• 发表时间: 2013
• 影响因子: 2.2
• 作者: Miki A; Ikuno Y; Jo Y; Nishida K
• 通讯作者: Nishida K

Risk factors for development of full-thickness macular holes after pars plana vitrectomy for myopic foveoschisis

近视黄斑中心凹劈裂玻璃体切除术后发生全层黄斑裂孔的危险因素

• 发表时间: 2013
• 影响因子: 4.2
• 作者: Gao X; Ikuno Y; Fujimoto S; Nishida K
• 通讯作者: Nishida K

ARNに対する硝子体手術

ARN 玻璃体手术

• 发表时间: 2013
• 作者: 生野恭司

Intravitreal bevacizumab for choroidal neovasucularization from tilted disc syndrome

玻璃体内注射贝伐单抗治疗倾斜椎间盘综合征引起的脉络膜新生血管

• 发表时间: 2012
• 作者: Asai T;Ikuno Y;Nisida K
• 通讯作者: Nisida K

Commercially available rigid gas-permeable contact lens for protecting the cornea from drying during vitrectomy with a wide viewing system

市售硬质透气隐形眼镜，具有宽视野系统，可在玻璃体切除术过程中保护角膜免于干燥

• 发表时间: 2012
• 影响因子: 2.2
• 作者: Kamei M; Matsumura N; Sakaguchi H; Oshima Y; Ikuno Y; Nishida K
• 通讯作者: Nishida K