Simultaneous gradual lengthening of proximal and distal nerve stumps for repair of chronic peripheral nerve defect.

同时逐渐延长近端和远端神经残端以修复慢性周围神经缺损。

• 批准号: 23592155
• 负责人: OCHIAI Naoyuki
• 金额: $ 3.16万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592155/
• 关键词: 再生医学; 神経科学; 末梢神経伸長; 神経欠損治療; 筋・神経病学

We investigated nerve regeneration of rat sciatic nerves after chronic injury of 15 mm-defect by the gradual lengthening of proximal and distal nerve stumps. In the lengthened proximal stump, Schwann cells and axons existed along the whole nerve stump. In the lengthened distal stump, Schwann cells exist along the overall length. The whole nerve trunk was lengthened.The nerve regeneration was comparable with the delayed end-to-end suture without nerve defect. We showed the feasibility of direct gradual lengthening of proximal and distal nerve stumps for the treatment of chronic segmental nerve defect.

我们通过逐渐延长近端和远端神经残端来研究 15 毫米缺损慢性损伤后大鼠坐骨神经的神经再生。在加长的近端残端中，雪旺细胞和轴突沿着整个神经残端存在。在加长的远端残端中，施万细胞沿着整个长度存在。整个神经干被延长，神经再生效果与无神经缺损的延迟端到端缝合相当。我们展示了直接逐渐延长近端和远端神经残端治疗慢性节段神经缺损的可行性。

项目成果

Stimultaneous gradual lengthening of proximal and distal nerve stumps for repair of chronic peripheral nerve defect in rats

刺激逐渐延长近端和远端神经残端修复大鼠慢性周围神经缺损

• DOI: 10.1142/s0218810412500013
• 发表时间: 2013
• 作者: Nakajima Y; Nishiura Y; Hara Y; Sharula; Ochiai N
• 通讯作者: Ochiai N

末梢神経両断端緩徐伸長法による陳旧性末梢神経欠損の修復

通过缓慢延长周围神经残端修复陈旧性周围神经缺损

• 发表时间: 2013
• 作者: 中島佳子;西浦康正;原友紀;Sharula;落合直之
• 通讯作者: 落合直之

Simultaneous gradual lengthening of proximal and distal nerve stumps for repair of chronic peripheral nerve defect in rats.

同时逐渐延长近端和远端神经残端以修复大鼠慢性周围神经缺损。

• DOI: 10.1142/s0217732312500770
• 发表时间: 2014
• 作者: Nakajima Y; Nishiura Y; Hara Y; Sharula; Ochiai N.
• 通讯作者: Ochiai N.