Development of pH sensitive liposome for organic photovoltaics with fullerene

富勒烯有机光伏 pH 敏感脂质体的开发

• 批准号: 23560938
• 负责人: SHIROSAKI Tomohiro
• 金额: $ 3.49万
• 依托单位: Kumamoto Industrial Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23560938/
• 关键词: 太陽電池; 太陽光発電; 超分子化学; 合成化学; 再生可能エネルギー; リン脂質; リポソーム; ジスルフィド結合; 酸分解性; エステル結合; 有機薄膜太陽電池; フラーレン; 放出制御

Although liposome has been studied as a career of drug and gene delivery, there are some problems in the release of inclusions of liposome. In order to release drugs in a cell, liposome should be destabilized in acid enviroments such as inside of endocytic vesicles. In this study, we synthesized the phospholipids with disulfide groups in alkyl chains, and prepared pH-sensitive liposome using disulfide groups containing phospholipids. The phospholipid was synthesized from sn-glycero-3-phosphocholine and disulfide group containing fatty acid in the presence of N,N'-diisopropylcarbodiimide and 4-dimethylaminopyridine. The pH-sensitive liposome was prepared at pH7.4, and pH dependent destabilization of the liposome was investigated. pH-sensitive liposome was casted on ITO electrode which was used for organic photovoltaic, and terated with acid. The morphology of the liposome was changed by the treatment of acid.

尽管脂质体已作为药物和基因递送的事业而被研究，但脂质体包裹体的释放存在一些问题。为了在细胞中释放药物，脂质体应该在酸性环境（例如内吞囊泡内部）中不稳定。本研究合成了烷基链上带有二硫基的磷脂，并利用含二硫基的磷脂制备了pH敏感性脂质体。在N,N'-二异丙基碳二亚胺和4-二甲基氨基吡啶存在下，由sn-甘油-3-磷酸胆碱和含二硫基的脂肪酸合成磷脂。在pH7.4下制备pH敏感的脂质体，并研究了脂质体的pH依赖性去稳定性。将pH敏感的脂质体浇注在有机光伏用ITO电极上，并用酸处理。酸处理改变了脂质体的形态。

项目成果

有機/無機ハイブリッド微粒子を用いた色素増感太陽電池の高効率化に関する研究

利用有机/无机杂化粒子提高染料敏化太阳能电池效率的研究

• 作者: 山下 太輔; 堀川 真希; 城崎 智洋; 永岡 昭二; 高藤 誠; 伊原 博隆
• 通讯作者: 伊原 博隆

ガスバリア性コート剤

阻气涂层剂

• 发表时间: 2012

色素増感太陽電池

染料敏化太阳能电池

• 发表时间: 2011

Preparation and Characterization of Maltose-Pendant Polymer/Mica Nanocomposites and Their Application to Oxygen Gas Barrier Films

麦芽糖聚合物/云母纳米复合材料的制备、表征及其在氧气阻隔膜中的应用

• 发表时间: 2014
• 作者: H. Sakurai; S. Nagaoka; M. Horikawa; T. Shirosaki. Kubota; K. Hamada; M. Takafuji; H. Ihara
• 通讯作者: H. Ihara

Preparation and characterization of dispersible chitosan particles with borate crosslinking and their antimicrobial and antifungal activity

硼酸盐交联可分散壳聚糖颗粒的制备、表征及其抗菌抗真菌活性

• DOI: 10.1016/j.carres.2011.12.017
• 发表时间: 2012
• 影响因子: 3.1
• 作者: K. Saita; S. Nagaoka; T. Shirosaki; M. Horikawa; S. Matsuda; H. Ihara
• 通讯作者: H. Ihara