Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury

运动抑制大鼠脑外伤后神经元凋亡并改善脑功能

• 批准号: 23500629
• 负责人: ITOH Tatsuki
• 金额: $ 3.41万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500629/
• 关键词: リハビリテーション; 神経再生; 運動; 脳外傷; 高次脳機能改善; 酸化ストレス; アポトーシス; 神経保護作用; 神経再生促進効果; 神経細胞死; 高次機能改善

we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.

我们研究了运动对大鼠 TBI 后形态和脑功能的影响。 Wistar大鼠通过气动控制损伤装置接受TBI，并随机分为两组：1）非运动组和2）运动组。运动组在跑步机上跑步。 TBI 后进行了免疫组织化学和行为研究。 TBI 后早期，运动组的 ssDNA 阳性细胞数量显着减少。此外，非运动组中的大多数 ssDNA 阳性细胞与神经元细胞共定位。然而，在运动组中，很少有 ssDNA 阳性细胞共定位。此外，运动组TBI后神经元细胞数量显着增加，脑功能障碍得到改善。这些结果表明，TBI 后的运动可抑制神经元凋亡细胞死亡，从而改善脑功能障碍。

项目成果

Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats

乳蛋白可延缓易发生中风的自发性高血压大鼠中风的发生

• 发表时间: 2012
• 影响因子: 8.3
• 作者: Chiba T; Itoh T; Tabuchi M; Oshima K; Satou T; Ezaki O
• 通讯作者: Ezaki O

Increased apoptotic neuronal cell death And cerebral dysfunction after traumatic brain injury in aged rats

老年大鼠脑外伤后神经细胞凋亡增加和脑功能障碍

• 发表时间: 2013
• 影响因子: 3.1
• 作者: Itoh T; Imano M; Nishida S; Tsubaki M; Mizuguchi N; Hashimoto S; Ito A; Satou T
• 通讯作者: Satou T

(-)-Epigallocatechin-3-gallate increases the number of neural stem cells around the damaged area after rat traumatic brain injury

(-)-表没食子儿茶素-3-没食子酸酯增加大鼠脑外伤后受损区域周围神经干细胞的数量

• DOI: 10.1007/s00702-011-0764-9
• 发表时间: 2012
• 影响因子: 3.3
• 作者: Itoh T; Imano M; Nishida S; Tsubaki M; Hashimoto S; Ito A; Satou T
• 通讯作者: Satou T

Appearance of neural stem cells around the damaged area following traumatic brain injury in aged rats

老年大鼠脑外伤后受损区域周围神经干细胞的出现

• 发表时间: 2013
• 影响因子: 3.3
• 作者: Itoh T; Imano M; Tabuchi M; Munakata H; Hashimoto S; Ito A; Satou T
• 通讯作者: Satou T

Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2

在小鼠骨髓基质细胞系 ST2 中，双膦酸盐和他汀类药物通过抑制 Ras/MEK/ERK 通路和激活 p38MAPK 诱导 OPG 表达增强，并抑制 CD9、M-CSF 和 RANKL 表达

• 发表时间: 2012
• 影响因子: 4.1
• 作者: Tsubaki M ; Satou T; Itoh T; Imano M; Yanae M; Kato C; Takagoshi R; Komai M; Nishida S
• 通讯作者: Nishida S