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基本信息
- 批准号:23350060
- 负责人:
- 金额:$ 9.48万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1) Linkage between self-replication of DNA and self-reproduction of giant vesicles (GVs) was revealed on the basis of observation by optical microscopy and the populational analysis of groups of GVs. Although daughter GVs produced from the mother GV, were depleted with dNTP (deoxyNucleoside TriPhosphate), they adhered conveyer GVs filled with dNTP and fused with each other under the acidic condition. Hence daughter GVs acquired recursive ability; they were able to self-replicate DNA and self-divided after addition of the precursor of a membrane lipid. They also gave birth to granddaughters according to the same procedure. 3) It was found that this self-reproduction cycle consisted of four stages (Ingestion, Replication, Maturity, and Division), and each stage was promoted to the next by events which occurred in GVs.
1)基于光学显微镜观察和GV群体的群体分析,揭示了DNA自我复制和巨囊泡(GV)自我复制之间的联系。 尽管从母体 GV 产生的子体 GV 缺乏 dNTP(脱氧核苷三磷酸盐),但它们粘附在充满 dNTP 的传送带 GV 上,并在酸性条件下彼此融合。因此子GVs获得了递归能力;添加膜脂前体后,它们能够自我复制 DNA 并自我分裂。他们还按照同样的程序生下了孙女。 3)发现这个自我复制周期由四个阶段组成(摄取、复制、成熟和分裂),每个阶段都通过GV中发生的事件促进到下一个阶段。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
pH-Induced Switchable Vesicular Aggregation of Zwitterionic Phospholipids and Anionic Phospholipids
pH 诱导的两性离子磷脂和阴离子磷脂的可切换囊泡聚集
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:K. Suzuki; K. Kurihara; Y. Okura; T. Toyota; T. Sugawara
- 通讯作者:T. Sugawara
Self-Reproduction of Giant Vesicle Combined with Amplification of Encapsulated DNA
巨型囊泡的自我复制与封装 DNA 的扩增相结合
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Manipulating Molecular Electronics Composed of Redox of Redox-active π-systems
操纵由氧化还原活性π-系统的氧化还原组成的分子电子学
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Plenary Lecture; Cross-π-conjugated TTF-based Donor Radical as a Building Block of Molecular Spintronics
全体演讲;基于 TTF 的交叉π共轭供体自由基作为分子自旋电子学的构建模块
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:T. Sugawara
- 通讯作者:T. Sugawara
Emergence of Active Site for Self-reproducing Dyanmics in Vesicle-based Protocell
基于囊泡的原始细胞中自我复制动力学活性位点的出现
- DOI:
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:T. Sugawara
- 通讯作者:T. Sugawara
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SUGAWARA Tadashi其他文献
SUGAWARA Tadashi的其他文献
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{{ truncateString('SUGAWARA Tadashi', 18)}}的其他基金
Development of Novel Physical Properties Based on an Organic Coexisting System of Localized Spin and Conduction Electron
基于局域自旋和传导电子有机共存体系的新物理性质的发展
- 批准号:
20350062 - 财政年份:2008
- 资助金额:
$ 9.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Proto-cell Model Exhibiting Synchronized Self-replication Dynamics of Giant Vesicles and DNA
展示巨型囊泡和 DNA 同步自我复制动力学的原始细胞模型
- 批准号:
17350066 - 财政年份:2005
- 资助金额:
$ 9.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Construction of Super-Structured Spin-Polarized Donor having Spin-rectifying Property
具有自旋校正特性的超结构自旋偏振施主的构建
- 批准号:
13304056 - 财政年份:2001
- 资助金额:
$ 9.48万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of a high resolution solid-steate NMR spectrometer and investigation dynamical behavior of organic molecules in the solid state.
开发高分辨率固态核磁共振波谱仪并研究固态有机分子的动力学行为。
- 批准号:
02554016 - 财政年份:1990
- 资助金额:
$ 9.48万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
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