Elucidation and manipulation of the regulatory mechanisms of cellular functions by metabolic codes

通过代谢密码阐明和操纵细胞功能的调节机制

• 批准号: 21K19064
• 负责人: Miyamoto Takafumi
• 金额: $ 4.16万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Research (Exploratory)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-07-09 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19064/
• 关键词: 代謝; アミノ酸; 時空間的活性ダイナミクス; 栄養学; 合成生物学

项目成果

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice

糖尿病 db/db 小鼠胰岛血管对胰岛素抵抗的形态和功能适应受损

• DOI: 10.1016/j.bbadis.2022.166339
• 发表时间: 2022
• 期刊: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 作者: Okajima Yuka;Matsuzaka Takashi;Miyazaki Shun;Motomura Kaori;Ohno Hiroshi;Sharma Rahul;Shimura Takuya;Istiqamah Nurani;Han Song-iee;Mizunoe Yuhei;Osaki Yoshinori;Iwasaki Hitoshi;Yatoh Shigeru;Suzuki Hiroaki;Sone Hirohito;Miyamoto Takafumi;Aita Yuichi;Takeu
• 通讯作者: Takeu

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2

• DOI: 10.1016/j.bbrc.2021.05.069
• 发表时间: 2021-05-27
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kainoh, Kenta;Takano, Ryo;Shimano, Hitoshi
• 通讯作者: Shimano, Hitoshi

Heat shock‐induced heme oxygenase‐1 expression in a mouse hepatoma cell line is dependent on HSF1 and modified by NRF2 and BACH1

小鼠肝癌细胞系中热休克诱导的血红素加氧酶-1 表达依赖于 HSF1，并受 NRF2 和 BACH1 修饰

• DOI: 10.1111/gtc.12986
• 发表时间: 2022
• 期刊: Genes to Cells
• 影响因子: 2.1
• 作者: Inouye Sachiye;Kubo Takanori;Miyamoto Takafumi;Iyoda Takuya;Okita Naoyuki;Akagi Reiko
• 通讯作者: Akagi Reiko

Starvation‐induced transcription factor CREBH negatively governs body growth by controlling GH signaling

饥饿诱导的转录因子 CREBH 通过控制 GH 信号传导负调控身体生长

• DOI: 10.1096/fj.202002784rr
• 发表时间: 2021
• 期刊: The FASEB Journal
• 作者: Nakagawa Yoshimi;Kumagai Kae;Han Song‐iee;Mizunoe Yuhei;Araki Masaya;Mizuno Seiya;Ohno Hiroshi;Matsuo Kazuya;Yamada Yasunari;Kim Jun‐dal;Miyamoto Takafumi;Sekiya Motohiro;Konishi Morichika;Itoh Nobuyuki;Matsuzaka Takashi;Takahashi Satoru;Sone Hirohito;Shi
• 通讯作者: Shi

A case of NASH with genetic predisposition successfully treated with an SGLT2 inhibitor: a possible involvement of mitochondrial dysfunction.

使用 SGLT2 抑制剂成功治疗具有遗传倾向的 NASH 病例：可能涉及线粒体功能障碍。

• DOI: 10.1530/edm-22-0368
• 发表时间: 2022
• 期刊: Endocrinol Diabetes Metab Case Rep.
• 作者: Nakajima R;Sekiya M;Furuta Y;Miyamoto T;Sato M;Fukuda K;et;al.
• 通讯作者: al.