Challenge for Detoxification of Arsenic by Methylated Metal Complex

甲基化金属络合物解砷的挑战

• 批准号: 22655018
• 负责人: HISAEDA Yoshio
• 金额: $ 2.23万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22655018/
• 关键词: 金属錯体化学; 無機ヒ素; メチル化反応; ビタミンB_<12>; グルタチオン; チオール; コバルト錯体; 有害化学物質; ビタミンB12; 触媒反応; 金属錯体; コバルト-メチル結合; 環境技術; ヒ素

Inorganic arsenic has caused serious chronic diseases throughenvironmental pollution. However, some methylated arsenic compounds, especiallytrimethylarsine oxide(TMAO) and arsenobatetaine(AB) have much lower toxicities thanarsenic trioxide(As2O3). The acute toxicity of AB, as determined from animal experiments, is approximately one three-hundredth of that of arsenic trioxide. Meanwhile, in marineecosystems, inorganic arsenicals are biologically methylated through the food chain, whichinvolves a methyltransferase and a reductase. An interesting application of the methyltransfer reaction with vitamin B_<12> to the detoxification system for inorganic arsenic hasbeen succeeded. This is a new and selective detoxification method for inorganic arsenic, which is the biomimetic methylation of arsenic trioxide(As2O3) to give trimethylarsineoxide(TMAO).

无机砷通过环境污染导致严重的慢性疾病。然而，一些甲基化砷化合物，特别是三甲基胂氧化物（TMAO）和砷基丁酸（AB）的毒性远低于三氧化二砷（As2O3）。根据动物实验测定，AB的急性毒性约为三氧化二砷的百分之三。同时，在海洋生态系统中，无机砷通过食物链进行生物甲基化，其中涉及甲基转移酶和还原酶。与维生素B_12的甲基转移反应在无机砷解毒体系中的有趣应用已经成功。这是一种新型的无机砷选择性脱毒方法，即三氧化二砷（As2O3）仿生甲基化生成三甲基氧化胂（TMAO）。

项目成果

Eco-friendly Molecular Transformations Catalyzed by Vitamin B_ Derivative with Visible-Light-Driven System

可见光驱动系统下维生素 B_<12> 衍生物催化的环保分子转化

• DOI: 10.1039/c0gc00478b
• 发表时间: 2011
• 影响因子: 9.8
• 作者: K.Tahara; et al
• 通讯作者: et al

Photo-Induced Ring-Expansion Reactions Mediated by B_-TiO_2 Hybrid Catalyst

B_<12>-TiO_2 杂化催化剂介导的光致扩环反应

• 发表时间: 2010
• 作者: Izumi; S.; at al.
• 通讯作者: at al.

Bioinspired Catalysts Composed of VitaminB12 Derivative and Photosensitizers

由维生素B12衍生物和光敏剂组成的仿生催化剂

• 发表时间: 2011
• 作者: Y. Hisaeda

Methyl-transfer Reaction to Alkylthiol Catalyzed by a Simple Vitamin B_ Model Complex Using Zinc Powder

锌粉催化简单维生素 B_<12> 模型复合物向烷基硫醇的甲基转移反应

• DOI: 10.1016/j.ica.2011.01.004
• 发表时间: 2011
• 作者: L.Pan; et al
• 通讯作者: et al

Photo-Induced Ring-Expansion ReactionsMediated by B12-TiO2 Hybrid Catalyst

B12-TiO2 杂化催化剂介导的光致扩环反应

• 发表时间: 2010
• 作者: S. Izumi; H. Shimakoshi; M. Abe; Y. Hisaeda
• 通讯作者: Y. Hisaeda