Development of novel endothelial keratoplasty (nDSAEK) for bullous keratopathy and its visual function analysis

新型内皮角膜移植术（nDSAEK）治疗大疱性角膜病的发展及其视功能分析

• 批准号: 22591934
• 负责人: KOBAYASHI Akira
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591934/
• 关键词: 角膜移植; 角膜内皮移植; 角膜内皮移植術; DSAEK; nDSAEK; 共焦点顕微鏡; 水疱性角膜症

According to a research project, we conducted a research to compare the clinical results after DSAEK(Descemet stripping automated endothelial keratoplasty)and nDSAEK(non-Descemet stripping automated endothelial keratoplasty). As a result, no statistical difference was observed between these two groups in terms of the visual acuity, and best corrected visual acuity, endothelial cell density. Also, no differencewas observed for donor adherence rate. In vivo laser confocal microscopy revealed that subepithelial opacity, stromal needle shaped bodies, donor recipient interface opacity and particles. Most notably, giant hyperreflective materials were observed at donor recipient interface only in nDSAEK group; these were considered to be necrotic and aggregated host endothelial cells and seemed to have no side effect to postoperative visual acuity.

根据一项研究项目，我们进行了一项研究，比较DSAEK（后弹力层剥离自动化内皮角膜移植术）和nDSAEK（非后弹力层剥离自动化内皮角膜移植术）后的临床结果。结果，两组之间在视力、最佳矫正视力、内皮细胞密度方面没有观察到统计学差异。此外，捐赠者依从率也没有观察到差异。体内激光共聚焦显微镜显示上皮下混浊、基质针状体、供体受体界面混浊和颗粒。最值得注意的是，仅在 nDSAEK 组中，在供体受体界面处观察到巨大的超反射材料；这些被认为是坏死和聚集的宿主内皮细胞，并且似乎对术后视力没有副作用。

项目成果

Clinical significance of owl eye morphologic features by in vivo laser confocal microscopy in patients with cytomegalovirus corneal endothelitis

体内激光共聚焦显微镜观察巨细胞病毒角膜内皮炎患者眼部形态特征的临床意义

• 发表时间: 2012
• 影响因子: 4.2
• 作者: Kobayashi A; Yokogawa H; Higashide T; Nitta K; Sugiyama K
• 通讯作者: Sugiyama K

In vivo confocal microscopy and ultrasound biomicroscopy study of filtering blebs after trabeculectomy: limbus-based versus fornix-based conjunctival flaps

小梁切除术后滤过泡的体内共焦显微镜和超声生物显微镜研究：基于角膜缘的结膜瓣与基于穹窿的结膜瓣

• DOI: 10.1097/ijg.0b013e3182120a08
• 发表时间: 2012
• 影响因子: 2
• 作者: Morita K; Gao Y; Saito Y; Higashide T; Kobayashi A; Ohkubo S; Sugiyama K
• 通讯作者: Sugiyama K

Intraocular pressure after Descemet stripping and non-Descemet stripping automated endothelial keratoplasty

后弹力层剥离和非后弹力层剥离自动化角膜内皮移植术后眼压

• 发表时间: 2011
• 作者: Mawatari Y; Kobayashi A; Yokogawa H; Sugiyama K
• 通讯作者: Sugiyama K

アルゴンレーザー虹彩切開術後水疸性角膜症におけるnDSAEKの術後成績

nDSAEK 治疗氩激光虹膜切开术后含水性角膜病的术后结果

• 发表时间: 2011
• 作者: 正木利憲;小林顕;禎川英明;杉山和久
• 通讯作者: 杉山和久

Clinical results of non Descemet stripping automated endothelial keratoplasty.World Ophthalmology Congress

非后弹力层剥离自动化内皮角膜移植术的临床结果.世界眼科学大会

• 发表时间: 2010
• 作者: Masaki T; Kobayashi A; Yokogawa H; Sugiyama K.
• 通讯作者: Sugiyama K.