Elucidation of pathological condition in uveitis using newly developed carbohydrate structural analysis; Glycoblottoing

使用新开发的碳水化合物结构分析阐明葡萄膜炎的病理状况；

• 批准号: 22591927
• 负责人: NANBA Kenichi
• 金额: $ 2.91万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591927/
• 关键词: グライコミクス; ぶどう膜炎; 糖鎖; グライコプロッティング; EAU; 実験的自己免疫性ぶどう膜網膜炎; ベーチェット病; グライコブロッティング

Glycoblottoing which was newly developed carbohydrate structural analysis was performed in uveitis patients. In the serum of uveitis patients, total amount of carbohydrate was increased in uveitis patients, and 3 carbohydrate chains that amount were changed in the active stage were found. In Behcet’s disease, carbohydrate chains that were associated with HLA-B51 or exraocular manifestations were found, however carbohydrate chains that were associated with ocular inflammatory attacks were not found. In mouse model experimental autoimmune uveoretinitis, carbohydrate chains that were changed with immunization were found, but they were not specific changes associated with induced uveitis.

在葡萄膜炎患者中进行了新开发的碳水化合物结构分析，在葡萄膜炎患者的血清中，碳水化合物的总量增加，并且在白塞氏病中发现了3条碳水化合物链的量发生变化。发现了与 HLA-B51 或眼外表现相关的碳水化合物链，但在小鼠模型实验性自身免疫中未发现与眼部炎症发作相关的碳水化合物链。葡萄膜视网膜炎中，发现了因免疫而改变的碳水化合物链，但它们不是与诱发性葡萄膜炎相关的特异性变化。

项目成果

Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population

在韩国人群中复制白塞氏病的微卫星全基因组关联研究

• DOI: 10.1093/rheumatology/ker444
• 发表时间: 2012
• 影响因子: 5.5
• 作者: Horie Y; et al
• 通讯作者: et al

Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients

日本患者 TLR9 基因多态性与 VKH 的关联性研究

• DOI: 10.3109/09273948.2011.553981
• 发表时间: 2011
• 影响因子: 3.3
• 作者: Ito Ryuta;Ota Masao;Meguro Akira; et al
• 通讯作者: et al

Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis

结节病葡萄膜炎患者血清中表面活性蛋白 D（一种肺部疾病生物标志物）的升高

• 发表时间: 2010
• 影响因子: 2.4
• 作者: Kitaichi N; Kitamura M; Namba K; Ishida S; Ohno S
• 通讯作者: Ohno S

Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA

用小干扰 RNA 阻断骨桥蛋白预防实验性自身免疫性葡萄膜视网膜炎

• 发表时间: 2010
• 影响因子: 3.4
• 作者: Iwata D; Kitamura M; Kitaichi N; Saito Y; Kon S; Namba K;(他9名)
• 通讯作者: (他9名)

肺粟粒結核に伴う結核性眼内炎の1例

结核性眼内炎合并肺粟粒结核1例

• 发表时间: 2012
• 作者: 長谷敬太郎;南場研一;竹本裕子;齋藤航;中村佳代子;今野哲;網島優;大野重昭;石田晋
• 通讯作者: 石田晋