分子認識界面に立脚した選択部－センサ一体型システムによる肺がんマーカー分子の識別

基于分子识别接口的选择单元-传感器集成系统识别肺癌标志分子

• 批准号: 18J12622
• 负责人: ZHU Zetao
• 金额: $ 0.96万
• 依托单位: Nagoya University (2019)Kyushu University (2018)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-25 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18J12622/
• 关键词: biosensor; kirkendall effect; porous surface; Metal oxide nanowires; Vapor liquid solid; Impurity doping; Carrier density control; Doping homogeneity

Porous structure is proved as a promising structure for capturing the biomolecules. However, the difficulty for integration of the porous structure on the channel of electrical nanosensors have limited the application.Here I proposed an original strategy of creating a kirkendall effect induced porous structure on ZnO channel of transistor-based biosensor. The porous structure was in-situ fabricated by annealing of an Al2O3 covered ZnO nanobeam. The formation of the porous structure was assigned to the kirkendall effect of different diffusion rates of Al and Zn at the interface of Al2O3/ZnO. At last, the sensing response to the CRP analytes was observed by the integrated electrical biosensor. We believe that this original strategy will be a foundation for designing a new type of porous-based biosensors.

多孔结构被证明是一种有前途的捕获生物分子的结构。然而，多孔结构在电纳米传感器通道上集成的困难限制了其应用。在这里，我提出了一种在基于晶体管的生物传感器的ZnO通道上创建柯肯达尔效应诱导的多孔结构的原创策略。该多孔结构是通过对 Al2O3 覆盖的 ZnO 纳米束进行退火而原位制造的。多孔结构的形成归因于Al2O3/ZnO界面上Al和Zn不同扩散速率的柯肯达尔效应。最后，通过集成电生物传感器观察到对 CRP 分析物的传感响应。我们相信，这种原始策略将成为设计新型多孔生物传感器的基础。

项目成果

Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse

• DOI: 10.2116/analsci.20n002
• 发表时间: 2020-09-01
• 期刊: ANALYTICAL SCIENCES
• 影响因子: 1.6
• 作者: Liu, Quanli;Yasui, Takao;Baba, Yoshinobu
• 通讯作者: Baba, Yoshinobu

Dual Impact of Impurity on Crystal Growth Interface and Electrical Homogeneity of Metal Oxide Nanowires in Vapor-Liquid-Solid Process

气-液-固过程中杂质对金属氧化物纳米线晶体生长界面和电均匀性的双重影响

• 发表时间: 2018
• 作者: Z. Zhu;T. Takahashi;K. Nagashima;M. Suzuki;M. Kanai;G. Zhang;H. Anzai and T. Yanagida
• 通讯作者: H. Anzai and T. Yanagida