Hearing loss against patients of diabetes mellitus.

糖尿病患者的听力损失。

• 批准号: 22791639
• 负责人: FUKUSHIMA Hisaki
• 金额: $ 2.58万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791639/
• 关键词: 耳科学; 糖尿病; 内耳障害; 感音難聴; 突発性難聴; ヒト側頭骨病理; 蝸牛

Hearing loss against patients of diabetes mellitus bjectives : To evaluate the effects of diabetes on cochlear elements in humans.Methods : 26 temporal bones(mean age, 37.5 years) with type 1 diabetes and 30 age-matched controls were examined by light microscopy. We compared the findings of cochlear vessels, hair cells, spiral ganglion cells and cochlear lateral walls.Results : In diabetics, the walls of vessels of the basilar membrane(P<0.001) and vessels of the stria vascularis were(P<0.01) significantly thicker in all turns and loss of outer hair cells(OHCs) was significantly greater in the lower basal turn(P<0.01). Atrophy of the stria vascularis in all turns(P<0.0001) and loss of spiral ligament cells in upper turns(P<0.01) were significantly higher than controls. No significant difference was obtained in the number of spiral ganglion cells between groups.Conclusion : This study suggests that type 1 diabetes mellitus causes cochlear microangiopathy and degeneration of cochlear lateral walls and OHCs.

糖尿病患者的听力损失 目标：评估糖尿病对人类耳蜗元件的影响。方法：通过光学显微镜检查 26 名患有 1 型糖尿病的颞骨（平均年龄，37.5 岁）和 30 名年龄匹配的对照者。我们比较了耳蜗血管、毛细胞、螺旋神经节细胞和耳蜗侧壁的结果。结果：糖尿病患者的基底膜血管壁（P<0.001）和血管纹血管壁（P<0.01）显着升高。所有毛圈均较粗，且下基底毛圈的外毛细胞（OHC）损失明显较多（P<0.01）。各圈血管纹萎缩(P<0.0001)和上圈螺旋韧带细胞丢失(P<0.01)均显着高于对照组。各组之间螺旋神经节细胞的数量没有显着差异。结论：本研究表明1型糖尿病导致耳蜗微血管病变以及耳蜗侧壁和OHC的变性。

项目成果

生活習慣病と耳鼻咽喉科疾患ENTONI

生活方式相关疾病和耳鼻喉科疾病 ENTONI

• 发表时间: 2011
• 作者: 福島久毅

当科における突発性難聴の検討

我科突发性耳聋检查

• 发表时间: 2011
• 作者: 福島久毅

突発性難聴の検討

考虑突发性听力损失

• 发表时间: 2011
• 作者: 福島久毅

ENTONI生活習慣病と耳鼻咽喉科疾患

ENTONI生活方式相关疾病及耳鼻喉科疾病

• 发表时间: 2011
• 作者: 原田保

Sudden sensorineural hearing loss and Aging

突发感音神经性听力损失与衰老

• 发表时间: 2011
• 作者: Hisaki Fukushima