Basic research about leg dysfunction in spina bifida

脊柱裂腿部功能障碍的基础研究

• 批准号: 22591637
• 负责人: MATSUDA Seiji
• 金额: $ 3万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591637/
• 关键词: 二分脊椎; 歩行異常; ニワトリ; インターニューロン; 感覚神経; シナプス; 二足歩行; 神経回路; 回路異常; 筋の神経支配; Islet-1; 運動ニューロン; 感覚神経の走行異常; ヒヨコ; 運動障害

We developed surgery-induced chick SBA(1) SBA chicks exhibited leg muscle paralysis.(2) Histological analyses revealed fewer interneurons in SBA chicks than in normal chicks, but no difference was observed in the number of motor neurons.(3) a defect in the production and elimination of excess motor neurons during the early developmental stages in SBA chicks may be involved in the pathological mechanism of the motor complications of this disease.(4) The dorsal funiculus was smaller in hatched SBA chicks than in the normal controls. Degenerated sensory nerve fibers were observed in all funiculi of SBA chicks.(5) Delay in synaptogenesis and tissue maturation in SBA chicks was shown.

我们开发了手术诱导雏鸡 SBA (1) SBA 雏鸡表现出腿部肌肉麻痹。(2) 组织学分析显示 SBA 雏鸡的中间神经元比正常雏鸡少，但运动神经元的数量没有观察到差异。(3) 缺陷SBA雏鸡发育早期多余运动神经元的产生和消除可能参与了该病运动并发症的病理机制。(4)孵化的SBA雏鸡背索较小与正常对照相比。在SBA雏鸡的所有索中均观察到退化的感觉神经纤维。(5)显示SBA雏鸡的突触发生和组织成熟延迟。

项目成果

Prosaposin-derived peptide alleviates ischaemia-induced hearing loss.

Prosaposin 衍生肽可减轻缺血引起的听力损失。

• 发表时间: 2013
• 影响因子: 1.4
• 作者: T Terashita; S Saito; H Nabeka; N Hato; H Wakisaka; T Shimokawa; N Kobayashi; K Gyo; S Matsuda
• 通讯作者: S Matsuda

3) Distribution of prosaposin in rat lymphatic tissues

3）prosaposin在大鼠淋巴组织中的分布

• 发表时间: 2013
• 影响因子: 3.6
• 作者: T Shimokawa

4) Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice

4) mdx和心脏毒素治疗小鼠再生肌肉中Prosaposin的表达

• 发表时间: 2013
• 作者: C Li

Developmental delay in Islet-1-positive motor neurons in chick spina bifida.

鸡脊柱裂中 Islet-1 阳性运动神经元发育迟缓。

• 发表时间: 2011
• 影响因子: 1.2
• 作者: Min Wang; et al.
• 通讯作者: et al.

Zonisamide attenuates MPTP neurotoxicity in marmosets.

Zonisamide 可减轻狨猴中的 MPTP 神经毒性。

• 发表时间: 2010
• 影响因子: 3.5
• 作者: ME Choudhury; T Moritoyo; H Yabe; N Nishikawa; M Nagai; M Kubo ; S Matsuda; M Nomoto
• 通讯作者: M Nomoto