Molecular and morphological studies on roles of autophagy in tick starvation periods and their transmission of protozoan parasites.

关于自噬在蜱饥饿期间的作用及其原生动物寄生虫传播的分子和形态学研究。

• 批准号: 22580356
• 负责人: MATSUO Tomohide
• 金额: $ 2.91万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580356/
• 关键词: マダニ媒介性疾病; フタトゲチマダニ; ピロプラズマ; 生存戦略; 節足動物; 原虫病; マダニ; 飢餓耐性; ベクター; 寄生虫; 原虫媒介

Ticks can feed a blood meal from most vertebrates except for fish and ingest a large amount of blood from hosts. Additionally, they seem to have a unique strategy to endure the off-host state for a long period. Autophagy is induced by starvation condition and is essential for life-span extention, therefore we speculate that autophagy also occurs in ticks. Some autophagy-related genes were isolated in Haemaphysalis longicornis, the most dominant tick in Japanese pastures and vector of piroplasmosis among grazing cattle, and then they were expressed during their unfed and moulting periods. It showed that autophagy plays an important role in tick suvival during long starvation periods.

蜱虫可以吸食除鱼类以外的大多数脊椎动物的血粉，并摄入宿主的大量血液。此外，他们似乎有一种独特的策略来长期忍受脱离主机的状态。自噬是由饥饿条件诱导的，对于延长寿命至关重要，因此我们推测自噬也发生在蜱中。在日本牧场最主要的蜱虫和放牧牛梨形虫病载体长角血蜱中分离出一些自噬相关基因，并在其不喂食和换毛期表达。结果表明，自噬在蜱虫长期饥饿期间的生存中发挥着重要作用。

项目成果

Parasiticidal activity of Haemaphysalis longicornis longicin against Toxoplasma gondii

长角血蜱素对弓形虫的杀寄生虫活性

• 发表时间: 2011
• 作者: Tanaka; T.; et al
• 通讯作者: et al

Parasiticidal activity of Haemaphysalis longicornis longicin P4 peptide against Toxoplasma gondii

长角血蜱长霉素P4肽对弓形虫的杀寄生虫活性

• DOI: 10.1016/j.peptides.2011.07.027
• 发表时间: 2012
• 影响因子: 3
• 作者: Tanaka T; Maeda H; Matsuo T; Boldbattar D; Umemiya
• 通讯作者: Umemiya

Autophagy and its physiological relevance in arthropods: Current knowledge and perspectives

自噬及其在节肢动物中的生理相关性：当前知识和观点

• DOI: 10.4161/auto.6.5.11962
• 发表时间: 2010
• 影响因子: 13.3
• 作者: Malagoli; D.; F. C. Abdalla; Y. Cao; Q. Feng; K. Fujisaki; A. Gregorc; T. Matsuo; I. P. Nezis; I. S. Papassideri; M. Sass; E. C. Silva;R. Umemiya
• 通讯作者: R. Umemiya

マダニのオートファジー関連遺伝子とその役割

蜱中自噬相关基因及其作用

• 发表时间: 2012
• 作者: 白藤(梅宮)梨可; ら
• 通讯作者: ら

Fujisaki (2010) Increased expression of ATG genes during non-feeding periods in the tick Haemaphysalis longicornis

Fujisaki (2010) 长角血蜱在非进食期间 ATG 基因的表达增加

• DOI: 10.4161/auto.6.4.11668
• 发表时间: 2010
• 影响因子: 13.3
• 作者: Umemiya;K
• 通讯作者: K