Genetic variants of alcohol metabolizing enzymes in Cardiovascular Disorders

心血管疾病中酒精代谢酶的遗传变异

• 批准号: 17K09495
• 负责人: Hayashi Hideki
• 金额: $ 3.08万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09495/
• 关键词: アルコール代謝酵素; 遺伝子多型; ブルガダ症候群; 心室細動発作; ADH1B; ALDH2; 循環器・高血圧; 遺伝子; 不整脈; 遺伝; ADH1B遺伝子; ALDH2遺伝子; アセトアルデヒド; 酵素; アルコール; アルコール依存症; 突然死

项目成果

Flecainide ameliorates arrhythmogenicity through NCX flux in Andersen-Tawil syndrome-iPS cell-derived cardiomyocytes.

• DOI: 10.1016/j.bbrep.2017.01.002
• 发表时间: 2017-03
• 期刊: Biochemistry and biophysics reports
• 影响因子: 2.7
• 作者: Kuroda Y;Yuasa S;Watanabe Y;Ito S;Egashira T;Seki T;Hattori T;Ohno S;Kodaira M;Suzuki T;Hashimoto H;Okata S;Tanaka A;Aizawa Y;Murata M;Aiba T;Makita N;Furukawa T;Shimizu W;Kodama I;Ogawa S;Kokubun N;Horigome H;Horie M;Kamiya K;Fukuda K
• 通讯作者: Fukuda K

Complex aberrant splicing in the induced pluripotent stem cell?derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation

携带 KCNQ1-A344Asp1 突变的长 QT 综合征患者诱导多能干细胞衍生心肌细胞中的复杂异常剪接

• DOI: 10.1016/j.hrthm.2018.05.028
• 发表时间: 2018
• 期刊: Heart Rhythm
• 影响因子: 5.5
• 作者: Wuriyanghai Yimin;Makiyama Takeru;Sasaki Kenichi;Kamakura Tsukasa;Yamamoto Yuta;Hayano Mamoru;Harita Takeshi;Nishiuchi Suguru;Chen Jiarong;Kohjitani Hirohiko;Hirose Sayako;Yokoi Fumika;Gao Jingshan;Chonabayashi Kazuhisa;Watanabe Ken;Ohno Seiko;Yoshida Yos
• 通讯作者: Yoshida Yos

Population pharmacokinetics and pharmacodynamics of apixaban linking its plasma concentration to intrinsic activated coagulation factor X activity in Japanese patients with atrial fibrillation

日本心房颤动患者中阿哌沙班的群体药代动力学和药效学将其血浆浓度与内在活化凝血因子 X 活性联系起来

• DOI: 10.1208/s12248-019-0353-7
• 发表时间: 2019
• 期刊: The AAPS Journal
• 作者: Ueshima Satoshi;Hira Daiki;Tomitsuka Chiho;Nomura Miki;Kimura Yuuma;Yamane Takuya;Tabuchi Yohei;Ozawa Tomoya;Itoh Hideki;Horie Minoru;Terada Tomohiro;Katsura Toshiya
• 通讯作者: Katsura Toshiya

xcessive Ca2+ release from ryanodine receptors underlying a RyR2 mutation associated with cathecholaminergic polymorphic ventricular tachycardia

与儿茶酚胺能多形性室性心动过速相关的 RyR2 突变引起的兰尼碱受体过度释放 Ca2

• 发表时间: 2018
• 作者: 伊藤英樹;呉林なごみ;大野聖子;藤居祐介;加藤浩一;福山恵;高山幸一郎;渡邉昌也;安斉俊久;堀江 稔
• 通讯作者: 堀江 稔

A Novel SCN5A Frameshift Mutation Caused Progressive Cardiac Conduction Disorder and Multiform Ventricular Arrhythmia in a Case with a Surgical-Repair History of Congenital Heart Disease.

一种新的 SCN5A 移码突变在一例有先天性心脏病手术修复史的病例中引起进行性心脏传导障碍和多形性室性心律失常。

• 发表时间: 2019
• 作者: Kato K;Ohno S;Ozawa T;Horie M.
• 通讯作者: Horie M.