The effects of Dysbiosis on intestinal stem cells, inflammation, and cancer

生态失调对肠道干细胞、炎症和癌症的影响

• 批准号: 17K09347
• 负责人: Shimpoh Takayuki
• 金额: $ 3万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09347/
• 关键词: 炎症性腸疾患; Dysbiosis; Notch; 消化管幹細胞; E-cadherin; 樹状細胞; Notch経路; 腸炎; 大腸癌; 幹細胞; 内科; 細菌; 細胞・組織; トランスレーショナルリサーチ; 免疫学

项目成果

Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer.

• DOI: 10.1186/s13099-017-0185-x
• 发表时间: 2017
• 期刊: Gut pathogens
• 影响因子: 4.2
• 作者: Shimpoh T;Hirata Y;Ihara S;Suzuki N;Kinoshita H;Hayakawa Y;Ota Y;Narita A;Yoshida S;Yamada A;Koike K
• 通讯作者: Koike K

Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case?Control Study, Human Cell Cultures, and In Vivo Preclinical Testing

α-受体阻滞剂作为结直肠癌的化学预防：病例对照研究、人类细胞培养和体内临床前测试的结果

• DOI: 10.1158/1940-6207.capr-18-0288
• 发表时间: 2019
• 期刊: Cancer Prevention Research
• 影响因子: 3.3
• 作者: Suzuki Nobumi;Niikura Ryota;Ihara Sozaburo;Hikiba Yohko;Kinoshita Hiroto;Higashishima Naoko;Hayakawa Yoku;Yamada Atsuo;Hirata Yoshihiro;Nakata Ryo;Okamoto Makoto;Sano Munetaka;Kushiyama Akifumi;Ichinose Mari;Woods Susan L.;Worthley Daniel;Iwamoto Yasuhiko
• 通讯作者: Iwamoto Yasuhiko

Role of Muscarinic Acetylcholine Signaling in Gastrointestinal Cancers

• DOI: 10.3390/biomedicines7030058
• 发表时间: 2019-09-01
• 期刊: BIOMEDICINES
• 影响因子: 4.7
• 作者: Konishi, Mitsuru;Hayakawa, Yoku;Koike, Kazuhiko
• 通讯作者: Koike, Kazuhiko

Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease

• DOI: 10.1093/ecco-jcc/jjy088
• 发表时间: 2018-10-01
• 期刊: JOURNAL OF CROHNS & COLITIS
• 影响因子: 8
• 作者: Ihara, Sozaburo;Hirata, Yoshihiro;Koike, Kazuhiko
• 通讯作者: Koike, Kazuhiko

BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice

• DOI: 10.1053/j.gastro.2018.11.024
• 发表时间: 2019-03-01
• 期刊: GASTROENTEROLOGY
• 影响因子: 29.4
• 作者: Hayakawa, Yoku;Tsuboi, Mayo;Wang, Timothy C.
• 通讯作者: Wang, Timothy C.